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Salvatore Assenza

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Hierarchical Protofilament Intertwining Rules the Formation of Mixed-Curvature Amyloid Polymorphs

Giovanni Dietler, Henning Paul-Julius Stahlberg, Meltem Tatli, Francesco Simone Ruggeri, Jiangtao Zhou, Salvatore Assenza, Raffaele Mezzenga

Amyloid polymorphism is a hallmark of almost all amyloid species, yet the mechanisms underlying the formation of amyloid polymorphs and their complex architectures remain elusive. Commonly, two main mesoscopic topologies are found in amyloid polymorphs cha ...

Wiley2024

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Detailed understanding of the mechanism by which Hsp70 chaperones protect cells against protein aggregation is hampered by the lack of a comprehensive characterization of the aggregates, which are typically heterogeneous. Here we designed a reporter chaper ...

NATURE PORTFOLIO2022

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Hsp70 molecular chaperones are abundant ATP-dependent nanomachines that actively reshape non-native, misfolded proteins and assist a wide variety of essential cellular processes. Here, we combine complementary theoretical approaches to elucidate the struct ...

2019

Shape of a Stretched Polymer

Paolo De Los Rios, Salvatore Assenza, Alberto Stefano Sassi

The shape of a polymer plays an important role in its interactions with surrounding molecules. We characterize the shape and the orientational properties of a polymer chain under tension in a good solvent, a physical condition that is often realized both i ...

American Physical Society2017

The Shape of a Stretched Polymer

Paolo De Los Rios, Salvatore Assenza, Alberto Stefano Sassi

The shape of a polymer plays an important role in determining its interactions with other molecules and with the environment, and is in turn affected by both of them. As a consequence, in the literature the shape properties of a chain in many different con ...

2017

Polymer-theory insights into biomolecular systems

Salvatore Assenza

Boosted by the technological advances in experimental techniques, cellular biology is nowadays facing the need for quantitative approaches in order to rationalize the huge amount of collected data. A particularly succesfull theoretical framework is provide ...

EPFL2015

Universal Behavior in the Mesoscale Properties of Amyloid Fibrils

Paolo De Los Rios, Salvatore Assenza, Raffaele Mezzenga

Amyloid fibrils are ubiquitous proteinaceous aggregates occurring in vivo and in vitro, with an invariant structural fingerprint at the molecular length scale. However, interpretation of their mesoscopic architectures is complicated by diverse observable p ...

2014

Emerging Meso- and Macroscales from Synchronization of Adaptive Networks

Salvatore Assenza

We consider a set of interacting phase oscillators, with a coupling between synchronized nodes adaptively reinforced, and the constraint of a limited resource for a node to establish connections with the other units of the network. We show that such a comp ...

American Physical Society2011