Publications de Salvatore Assenza

A fluorescent multi-domain protein reveals the unfolding mechanism of Hsp70

Paolo De Los Rios, Satyam Tiwari, Pierre Goloubinoff, Bruno Claude Daniel Fauvet, Salvatore Assenza

Detailed understanding of the mechanism by which Hsp70 chaperones protect cells against protein aggregation is hampered by the lack of a comprehensive characterization of the aggregates, which are typically heterogeneous. Here we designed a reporter chaper ...

NATURE PORTFOLIO2022

Efficient conversion of chemical energy into mechanical work by Hsp70 chaperones

Paolo De Los Rios, Alessandro Barducci, Alberto Stefano Sassi, Salvatore Assenza

Hsp70 molecular chaperones are abundant ATP-dependent nanomachines that actively reshape non-native, misfolded proteins and assist a wide variety of essential cellular processes. Here, we combine complementary theoretical approaches to elucidate the struct ...

2019

The Shape of a Stretched Polymer

Paolo De Los Rios, Salvatore Assenza, Alberto Stefano Sassi

The shape of a polymer plays an important role in determining its interactions with other molecules and with the environment, and is in turn affected by both of them. As a consequence, in the literature the shape properties of a chain in many different con ...

2017

Polymer-theory insights into biomolecular systems

Salvatore Assenza

Boosted by the technological advances in experimental techniques, cellular biology is nowadays facing the need for quantitative approaches in order to rationalize the huge amount of collected data. A particularly succesfull theoretical framework is provide ...

EPFL2015

Quantifying the role of chaperones in protein translocation by computational modeling

Paolo De Los Rios, Alessandro Barducci, Salvatore Assenza

2015

Universal Behavior in the Mesoscale Properties of Amyloid Fibrils

Paolo De Los Rios, Salvatore Assenza, Raffaele Mezzenga

Amyloid fibrils are ubiquitous proteinaceous aggregates occurring in vivo and in vitro, with an invariant structural fingerprint at the molecular length scale. However, interpretation of their mesoscopic architectures is complicated by diverse observable p ...

2014

Emerging Meso- and Macroscales from Synchronization of Adaptive Networks

Salvatore Assenza

We consider a set of interacting phase oscillators, with a coupling between synchronized nodes adaptively reinforced, and the constraint of a limited resource for a node to establish connections with the other units of the network. We show that such a comp ...

American Physical Society2011