Krisztian Homicsko

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Trametinib Induces the Stabilization of a Dual GNAQ p.Gly48Leu-and FGFR4 p.Cys172Gly-Mutated Uveal Melanoma. The Role of Molecular Modelling in Personalized Oncology

Olivier Michielin, Krisztian Homicsko, Alexandre Wicky

We report a case of an uveal melanoma patient with GNAQ p.Gly48Leu who responded to MEK inhibition. At the time of the molecular analysis, the pathogenicity of the mutation was unknown. A tridimensional structural analysis showed that G alpha(q) can adopt ...

2020

Unsorted single-cell RNA sequencing profiles of metastatic melanoma patients reveal the heterogeneity of melanoma-associated fibroblasts

Douglas Hanahan, Marco Matter, Krisztian Homicsko

OXFORD UNIV PRESS2019

T cell–induced CSF1 promotes melanoma resistance to PD1 blockade

Michele De Palma, George Coukos, Krisztian Homicsko, Sina Nassiri, Natacha Anne-Sophie Bordry, Esther Danenberg, Laure Tillé, Christophe Martignier

Colony-stimulating factor 1 (CSF1) is a key regulator of monocyte/macrophage differentiation that sustains the protumorigenic functions of tumor-associated macrophages (TAMs). We show that CSF1 is expressed in human melanoma, and patients with metastatic m ...

2018

Proton pump inhibitors negatively impact survival of PD-1 inhibitor based therapies in metastatic melanoma patients

Douglas Hanahan, Krisztian Homicsko

OXFORD UNIV PRESS2018

Tumor lymphangiogenesis promotes T cell infiltration and potentiates immunotherapy in melanoma

Melody Swartz, Douglas Hanahan, Olivier Michielin, Krisztian Homicsko, Marcela Rincón-Restrepo, Christopher Claude Giuseppe Tremblay, Amanda Waite Lund, Laura Jeanbart, Lambert Charles François Potin, Manuel Andreas Fankhauser

In melanoma, vascular endothelial growth factor-C (VEGF-C) expression and consequent lymphangiogenesis correlate with metastasis and poor prognosis. VEGF-C also promotes tumor immunosuppression, suggesting that lymphangiogenesis inhibitors may be clinicall ...

Amer Assoc Advancement Science2017

Compact solid-state CMOS single-photon detector array for in vivo NIR fluorescence lifetime oncology measurements

Edoardo Charbon, Claudio Bruschini, François Eric Powolny, Harald Arjan Robert Homulle, Krisztian Homicsko, Riccardo Sinisi, David Li

In near infrared fluorescence-guided surgical oncology, it is challenging to distinguish healthy from cancerous tissue. One promising research avenue consists in the analysis of the exogenous fluorophores' lifetime, which are however in the (sub-)nanosecon ...

2016

Combine and Conquer: Double CTLA-4 and PD-1 Blockade Combined with Whole Tumor Antigen Vaccine Cooperate to Eradicate Tumors

George Coukos, Krisztian Homicsko

2016

The consensus molecular subtypes of colorectal cancer

Douglas Hanahan, Anguraj Sadanandam, Krisztian Homicsko, Sarah Gerster, Paolo Angelino, Mauro Delorenzi, Xin Wang

Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and drug responses. To resolve inconsistencies among the reported gene expression-based CRC classifications and facilitate clinical translation, we formed an international c ...

Nature Publishing Group2015

Targeting Programmed Cell Death 1 in Ovarian Cancer

George Coukos, Krisztian Homicsko

Amer Soc Clinical Oncology2015

Time-resolved imaging system for fluorescence-guided surgery with lifetime imaging capability

Edoardo Charbon, Claudio Bruschini, Douglas Hanahan, François Eric Powolny, Harald Arjan Robert Homulle, Krisztian Homicsko, Riccardo Sinisi

We present a single-photon camera for fluorescence imaging, with a time resolution better than 100ps, capable of providing both intensity and lifetime images. the camera was fabricated in standard CMOS technology. With this FluoCam we show the possibility ...

Spie-Int Soc Optical Engineering2014

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Trametinib Induces the Stabilization of a Dual GNAQ p.Gly48Leu-and FGFR4 p.Cys172Gly-Mutated Uveal Melanoma. The Role of Molecular Modelling in Personalized Oncology

Olivier Michielin, Krisztian Homicsko, Alexandre Wicky

2020

Unsorted single-cell RNA sequencing profiles of metastatic melanoma patients reveal the heterogeneity of melanoma-associated fibroblasts

Douglas Hanahan, Marco Matter, Krisztian Homicsko

OXFORD UNIV PRESS2019

Combine and Conquer: Double CTLA-4 and PD-1 Blockade Combined with Whole Tumor Antigen Vaccine Cooperate to Eradicate Tumors

George Coukos, Krisztian Homicsko

2016