Lionel André Maurizi

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Effects of PVA coated nanoparticles on human immune cells

Heinrich Hofmann, Lionel André Maurizi

Nanotechnology provides new opportunities in human medicine, mainly for diagnostic and therapeutic purposes. The autoimmune disease rheumatoid arthritis (RA) is often diagnosed after irreversible joint structural damage has occurred. There is an urgent nee ...

Dove Medical Press Ltd2015

Transfer studies of polystyrene nanoparticles in the ex vivo human placenta perfusion model: key sources of artifacts

Heinrich Hofmann, Lionel André Maurizi

Nanotechnology is a rapidly expanding and highly promising new technology with many different fields of application. Consequently, the investigation of engineered nanoparticles in biological systems is steadily increasing. Questions about the safety of suc ...

Elsevier2015

Monitoring the effects of dexamethasone treatment by MRI using in vivo iron oxide nanoparticle-labeled macrophages

Heinrich Hofmann, Lionel André Maurizi, Géraldine Sylvie Coullerez

Introduction: Rheumatoid arthritis (RA) is a chronic disease causing recurring inflammatory joint attacks. These attacks are characterized by macrophage infiltration contributing to joint destruction. Studies have shown that RA treatment efficacy is correl ...

Biomed Central Ltd2014

A fast and reproducible method to quantify magnetic nanoparticle biodistribution

Heinrich Hofmann, Usawadee Sakulkhu, Lionel André Maurizi

The quantification of nanoparticles, particularly superparamagnetic iron oxide nanoparticles (SPIONs), both in vitro and in vivo has become highly important in recent years. Some methods, such as induced coupled plasma (ICP) spectroscopy and UV-visible che ...

Royal Society of Chemistry2014

Aqueous stabilisation of carbon-encapsulated superparamagnetic alpha-iron nanoparticles for biomedical applications

Heinrich Hofmann, Sandra Caroline Galmarini, Marie-Gabrielle Chantal Brigitte Ollivier Beuzelin, Lionel André Maurizi, Géraldine Sylvie Coullerez

Carbon-based nanomaterials, such as carbon-encapsulated magnetic nanoparticles (CEMNP, core@shell), show a wide range of desirable properties for applications in the biomedical field (clinical MRI, hyperthermia), for energy production and storage (hydrogen ...

Royal Society of Chemistry2014

Protein Corona Composition of Superparamagnetic Iron Oxide Nanoparticles with Various Physico-Chemical Properties and Coatings

Heinrich Hofmann, Usawadee Sakulkhu, Lionel André Maurizi, Jatuporn Salaklang, Morteza Mahmoudi

Because of their biocompatibility and unique magnetic properties, superparamagnetic iron oxide nanoparticles NPs (SPIONs) are recognized as some of the most prominent agents for theranostic applications. Thus, understanding the interaction of SPIONs with b ...

Nature Publishing Group2014

Ex situ evaluation of the composition of protein corona of intravenously injected superparamagnetic nanoparticles in rats

Heinrich Hofmann, Usawadee Sakulkhu, Marie-Gabrielle Chantal Brigitte Ollivier Beuzelin, Lionel André Maurizi, Morteza Mahmoudi

It is now well recognized that the surfaces of nanoparticles (NPs) are coated with biomolecules (e. g., proteins) in a biological medium. Although extensive reports have been published on the protein corona at the surface of NPs in vitro, there are very fe ...

Royal Soc Chemistry2014

Amino-polyvinyl Alcohol Coated Superparamagnetic Iron Oxide Nanoparticles are Suitable for Monitoring of Human Mesenchymal Stromal Cells In Vivo

Heinrich Hofmann, Lionel André Maurizi

Mesenchymal stromal cells (MSCs) are promising candidates in regenerative cell-therapies. However, optimizing their number and route of delivery remains a critical issue, which can be addressed by monitoring the MSCs' bio-distribution in vivo using super-p ...

Wiley-Blackwell2014

Syntheses of cross-linked polymeric superparamagnetic beads with tunable properties

Heinrich Hofmann, Usawadee Sakulkhu, Lionel André Maurizi, Vanessa Mai Dao

A novel, rapid and reproducible method to synthesize functionalized magnetic beads with an original shape is presented. By coating Fe2O3 nanoparticles with PVA, it was possible to tune the size, the number of iron oxide nanoparticles encapsulated and the o ...

RSC Publishing2014