Publications by Maroun Bou Sleiman

Systems genetics of metabolic health in the BXD mouse genetic reference population

Johan Auwerx, Xiaoxu Li, Jia Liu, Maroun Bou Sleiman, Wen Gao, Amélia Lalou, Alessia De Masi, Jean-David Horacio Morel

Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate genetic var ...

2024

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Johan Auwerx, Laurent Mouchiroud, Xiaoxu Li, Maroun Bou Sleiman, Elena Katsyuba, Wen Gao, Yang Li, Amélia Lalou, Gaby El Alam, Jean-David Horacio Morel

Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determinants in 85 C. e ...

2024

Hippo-YAP/TAZ signalling coordinates adipose plasticity and energy balance by uncoupling leptin expression from fat mass

Johan Auwerx, Xiaoxu Li, Maroun Bou Sleiman, Jun Yong Kim, Yoo Hoon Kim

Adipose tissues serve as an energy reservoir and endocrine organ, yet the mechanisms that coordinate these functions remain elusive. Here, we show that the transcriptional coregulators, YAP and TAZ, uncouple fat mass from leptin levels and regulate adipocy ...

Nature Portfolio2024

Mitochondrial matrix protein LETMD1 maintains thermogenic capacity of brown adipose tissue in male mice

Johan Auwerx, Xiaoxu Li, Maroun Bou Sleiman, Jun Yong Kim

Brown adipose tissue (BAT) has abundant mitochondria with the unique capability of generating heat via uncoupled respiration. Here, Park et al. identify LETMD1 as a mitochondrial matrix protein enriched in brown adipose tissue (BAT) and reveal a crucial ro ...

Nature Portfolio2023

ACMSD INHIBITION REDUCES HEPATIC INFLAMMATION AND FIBROSIS IN A MURINE THERMONEUTRALITY MODEL OF NASH

Johan Auwerx, Krisztian Homicsko, Xiaoxu Li, Jia Liu, Sandra Rodriguez Lopez, Richardus Houtkooper, Maroun Bou Sleiman, Keno Strotjohann

Lippincott Williams & Wilkins2023

INHIBITING SARM1 IS MORE EFFICACIOUS THAN NICOTINAMIDE RIBOSIDE SUPPLEMENTATION FOR THE TREATMENT OF A MOUSE MODEL WITH NAFLD/NASH

Johan Auwerx, Krisztian Homicsko, Xiaoxu Li, Jia Liu, Sandra Rodriguez Lopez, Richardus Houtkooper, Maroun Bou Sleiman, Keno Strotjohann

Lippincott Williams & Wilkins2023

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

Johan Auwerx, Sandra Rodriguez Lopez, Giacomo Vincenzo Giorgio Von Alvensleben, Maroun Bou Sleiman, Ludger Jan Elzuë Goeminne, Alexis Maximilien Bachmann, Jean-David Horacio Morel

Mice from different genetic backgrounds have widely diverse responses to the same metabolic challenges. Only PWK/PhJ mice show significant mitochondrial dysfunction and progression to fibrotic NASH that resembles human NASH. The PWK/PhJ strain is a novel N ...

ROCKEFELLER UNIV PRESS2023

Mitochondrial and NAD plus metabolism predict recovery from acute kidney injury in a diverse mouse population

Johan Auwerx, Giacomo Vincenzo Giorgio Von Alvensleben, Maroun Bou Sleiman, Dina Hofer, Yang Li, Alexis Maximilien Bachmann, Jean-David Horacio Morel

Acute kidney failure and chronic kidney disease are global health issues steadily rising in incidence and prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. Here, we ...

AMER SOC CLINICAL INVESTIGATION INC2023

Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Maroun Bou Sleiman, Alexis Rapin, Alexis Maximilien Bachmann, Jean-David Horacio Morel

Inflammatory gut disorders, including inflammatory bowel disease (IBD), can be impacted by dietary, environmental, and genetic factors. While the incidence of IBD is increasing worldwide, we still lack a complete understanding of the gene-by-environment in ...

2023

Sex- and age-dependent genetics of longevity in a heterogeneous mouse population

Johan Auwerx, Giacomo Vincenzo Giorgio Von Alvensleben, Hao Li, Maroun Bou Sleiman, Wen Gao

American Association for the Advancement of Science2022