Person
Arkadiy Bazhin
This person is no longer with EPFL
Related publications (5)
Mitochondrial copper depletion suppresses triple-negative breast cancer in mice
Elena Goun, Arkadiy Bazhin, Min Chen, Ji Qi
Depletion of mitochondrial copper, which shifts metabolism from respiration to glycolysis and reduces energy production, is known to be effective against cancer types that depend on oxidative phosphorylation. However, existing copper chelators are too toxi ...
NATURE RESEARCH2020Bioluminescent-based imaging and quantification of glucose uptake in vivo
Riccardo Sinisi, Elena Goun, Pavlo Khodakivskyi, Arkadiy Bazhin, Aleksey Yevtodiyenko, Tamara Maric, Georgy Mikhaylov
Glucose is a major source of energy for most living organisms, and its aberrant uptake is linked to many pathological conditions. However, our understanding of disease-associated glucose flux is limited owing to the lack of robust tools. To date, positron- ...
NATURE PUBLISHING GROUP2019A Universal Assay for Aminopeptidase Activity and Its Application for Dipeptidyl Peptidase-4 Drug Discovery
Gerardo Turcatti, Marc Chambon, Julien Bortoli Chapalay, Elena Goun, Jonathan Patrice Vesin, Arkadiy Bazhin, James William Collins
Aminopeptidases, such as dipeptidyl peptidase 4 (DPP-4, CD26), are potent therapeutic targets for pharmacological interventions because they play key roles in many important pathological pathways. To analyze amino-peptidase activity in vitro (including hig ...
AMER CHEMICAL SOC2019Novel probes for the non-invasive bioluminescence imaging of mitochondrial membrane potential and dipeptidylpeptidase-4 activity in living animals
Current thesis summarizes the work on development of novel bioluminescent probes for measurement of activity of dipeptidylpep-tidase-4 (DPP-4) and for quantification of mitochondrial membrane potential (MMP). DPP-4 enzyme plays critical role in develop-men ...
EPFL2018Bioorthogonal chemistry in bioluminescence imaging
Aurélien Godinat, Elena Goun, Arkadiy Bazhin
Bioorthogonal chemistry has developed significant over the past few decades, to the particular benefit of molecular imaging. Bioluminescence imaging (BLI) along with other imaging modalities have significantly benefitted from this chemistry. Here, we revie ...
ELSEVIER SCI LTD2018