Publications by Yann Christophe Sprunger

Biomarkers in Interstitial Fluid: From Screening to Sensor Development

EPFL2025

Bridging Blood and Skin: Biomarker Profiling in Dermal Interstitial Fluid (dISF) for Minimally Invasive Diagnostics

Mihai Adrian Ionescu, Yann Christophe Sprunger

Understanding the biochemical relationship between serum and dermal interstitial fluid (dISF) is critical for advancing minimally invasive diagnostics with wearables and point of care devices focusing on most relevant biomarkers accessible in the ISF. This ...

MDPI AG2025

AC-Driven Aptamer-Decorated Graphene FET for Cortisol Detection

Mihai Adrian Ionescu, Yann Christophe Sprunger, Ali Gilani, Sadegh Kamaei Bahmaei

Accurately measuring cortisol levels is crucial for diagnosing and managing stress-related conditions. Among all biofluids containing cortisol, Interstitial fluid (ISF) offers distinct advantages such as stable pH, continuous extraction, and minimal contam ...

Institute of Electrical and Electronics Engineers Inc.2024

Ultra-High Sensitivity Silicon Nanowire Array Biosensor Based on a Constant-Current Method for Continuous Real-Time pH and Protein Monitoring in Interstitial Fluid

Mihai Adrian Ionescu, Ali Saeidi, Yann Christophe Sprunger, Luca Capua

In this paper we demonstrate ultra-high sensitivity silicon nanowires pH and protein sensing on the same Silicon nanowire array platform by using a constant current method and monitoring the drain voltage as function of analyte concentration. The injected ...

IEEE2023

pH Quantification in Human Dermal Interstitial Fluid Using Ultra-Thin SOI Silicon Nanowire ISFETs and a High-Sensitivity Constant-Current Approach

Mihai Adrian Ionescu, Didier Locca, Yann Christophe Sprunger, Luca Capua

In this paper, we propose a novel approach to utilize silicon nanowires as high-sensitivity pH sensors. Our approach works based on fixing the current bias of silicon nanowires Ion Sensitive Field Effect Transistors (ISFETs) and monitor the resulting drain ...

MDPI2023

Label-Free C-Reactive Protein Si Nanowire FET Sensor Arrays With Super-Nernstian Back-Gate Operation

Mihai Adrian Ionescu, Yann Christophe Sprunger, Luca Capua, Felix Risch, Ron Gill, Aristea Grammoustianou

We present a CMOS-compatible double gate and label-free C-reactive protein (CRP) sensor, based on silicon on insulator (SOI) silicon nanowires arrays. We exploit a reference subtracted detection method and a super-Nernstian internal amplification given by ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2022