Publications by Chiara Cianciaruso

Determinants of tumor resistance to anti-angiogenic immunotherapy in mouse models of Kras-mutant NSCLC

Michele De Palma, Bruno Torchia, Etienne Meylan, Chiara Cianciaruso, Sina Nassiri, Ioanna Keklikoglou, Ece Kadioglu, Amaia Martinez Usatorre, Alan Nicolas Thierry Guichard

AMER ASSOC CANCER RESEARCH2021

Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models

Michele De Palma, Nadine Fournier, Bruno Torchia, Etienne Meylan, Chiara Cianciaruso, Sina Nassiri, Ioanna Keklikoglou, Ece Kadioglu, Gael Luis Boivin, Amaia Martinez Usatorre

Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of nonsmall cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and antiangiogenic d ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles

Hatice Altug, Michele De Palma, Chiara Cianciaruso, Filiz Yesilköy, Yasaman Jahani, Eduardo Romero Arvelo

Biosensors are indispensable tools for public, global, and personalized healthcare as they provide tests that can be used from early disease detection and treatment monitoring to preventing pandemics. We introduce single-wavelength imaging biosensors capab ...

Nature Research2021

All-dielectric Metasurfaces Enabling Imaging-based Real-time Biosensing

Hatice Altug, Michele De Palma, Chiara Cianciaruso, Yasaman Jahani, Eduardo Romero Arvelo

IEEE2021

Imaging-based Optofluidic Biosensors Enabled by All-dielectric metasurfaces

Hatice Altug, Michele De Palma, Chiara Cianciaruso, Yasaman Jahani, Eduardo Romero Arvelo

We present optofluidic label-free biosensors leveraging high quality-factor resonances emanated from bound-states-in-the-continuum and novel data processing. The sensors are based on imaging and offer solutions to remove sophisticated spectroscopy instrume ...

IEEE2021

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

Ioanna Keklikoglou, Michele De Palma, Mario Leonardo Squadrito, Chiara Cianciaruso, Esra Güç, Alan Nicolas Thierry Guichard, Antonino Cassarà

Cytotoxic chemotherapy is an effective treatment for invasive breast cancer. However, experimental studies in mice also suggest that chemotherapy has pro-metastatic effects. Primary tumours release extracellular vesicles (EVs), including exosomes, that can ...

2019

Molecular Profiling and Functional Analysis of Macrophage-Derived Tumor Extracellular Vesicles

Michele De Palma, Romain Hamelin, Bruno Torchia, Chiara Cianciaruso, Sina Nassiri, Tim Beltraminelli

Extracellular vesicles (EVs), including exosomes, modulate multiple aspects of cancer biology. Tumor-associated macrophages (TAMs) secrete EVs, but their molecular features and functions are poorly characterized. Here, we report methodology for the enrichm ...

2019

Macrophage interference on chemotherapy

Michele De Palma, Chiara Cianciaruso, Sina Nassiri

NATURE PUBLISHING GROUP2019

Mechanism and effects of pulsatile GABA secretion from cytosolic pools in the human beta cell

Steinunn Baekkeskov Hanahan, Chiara Cianciaruso, Petra Catalina Schwalie, Edward Allen Phelps

Pancreatic beta cells synthesize and secrete the neurotransmitter GABA (gamma-aminobutyric acid) as a paracrine and autocrine signal to help regulate hormone secretion and islet homeostasis. Islet GABA release has classically been described as a secretory- ...

2019

EVIR: Chimeric receptors that enhance dendritic cell cross-dressing with tumor antigens

Michele De Palma, Mario Leonardo Squadrito, Chiara Cianciaruso, Sarah Kate Hansen

We describe a lentivirus-encoded chimeric receptor, termed extracellular vesicle (EV)-internalizing receptor (EVIR), which enables the selective uptake of cancer-cell-derived EVs by dendritic cells (DCs). The EVIR enhances DC presentation of EV-associated ...

2018