Person
Hadrien Charles Edouard Demagny
Related publications (5)
A microbial-derived succinylated bile acid to safeguard liver health
Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny
In this issue of Cell, Nie and co-authors report that the microbe-derived bile acid (BA) 3-succinylated cholic acid protects against the progression of metabolic dysfunction-associated liver disease. Intriguingly, its protective mechanism does not involve ...
Cell Press2024Emerging functions of the nuclear receptor LRH-1 in liver physiology and pathology
Kristina Schoonjans, Hadrien Charles Edouard Demagny, Yu Sun
Nuclear receptors play pleiotropic roles in cell differentiation, development, proliferation, and metabolic processes to govern liver physiology and pathology. The nuclear receptor, liver receptor homolog-1 (LRH-1, NR5A2), originally identified in the live ...
2021Molecular physiology of bile acid signaling in health, disease, and aging
Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Laura Alejandra Velazquez Villegas
Over the last two decades, bile acids (BAs) have become established as important signaling molecules that enable fine-tuned inter-tissue communication from the liver, their site of production, over the intestine, where they are modified by the gut microbio ...
2021Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease
Kristina Schoonjans, Vera Monica Lemos Da Silva, Hadrien Charles Edouard Demagny, Dongryeol Ryu, Xu Wang, Matthias Alexander Sokrates Stein, Maaike Hélène Oosterveer, Pan Xu
Hepatic steatosis is caused by metabolic imbalances that could be explained in part by an increase in de novo lipogenesis that results from increased sterol element binding protein 1 (SREBP-1) activity. The nuclear receptor liver receptor homolog 1 (LRH-1) ...
Amer Soc Clinical Investigation Inc2017LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer
Johan Auwerx, Kristina Schoonjans, Hadrien Charles Edouard Demagny, Arnaud Comment, Dongryeol Ryu, Xu Wang, Norman Lionel Moullan, Emine Can, Matthias Alexander Sokrates Stein, Maaike Hélène Oosterveer, Pan Xu
Various tumors develop addiction to glutamine to support uncontrolled cell proliferation. Here we identify the nuclear receptor liver receptor homolog 1 (LRH-1) as a key regulator in the process of hepatic tumorigenesis through the coordination of a noncan ...
Cold Spring Harbor Laboratory2016