Publications by Carmen Alina Lupascu

Community-based reconstruction and simulation of a full-scale model of region CA1 of rat hippocampus

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King, Lida Kanari, Ying Shi, Armando Romani, Davide Bella, Felix Schürmann

The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive functions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, i ...

2024

The EBRAINS Hodgkin-Huxley Neuron Builder: An online resource for building data-driven neuron models

Jean-Denis Georges Emile Courcol, Michele Migliore, Genrich Ivaska, Carmen Alina Lupascu, Luca Leonardo Bologna, Shailesh Appukuttan

In the last decades, brain modeling has been established as a fundamental tool for understanding neural mechanisms and information processing in individual cells and circuits at different scales of observation. Building data-driven brain models requires th ...

FRONTIERS MEDIA SA2022

HippoUnit: A software tool for the automated testing and systematic comparison of detailed models of hippocampal neurons based on electrophysiological data

Eilif Benjamin Muller, Armando Romani, Werner Alfons Hilda Van Geit, Szabolcs Kali, Carmen Alina Lupascu, Rosanna Migliore, Luca Leonardo Bologna, Sàra Sàray, Shailesh Appukuttan

Anatomically and biophysically detailed data-driven neuronal models have become widely used tools for understanding and predicting the behavior and function of neurons. Due to the increasing availability of experimental data from anatomical and electrophys ...

2021

The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow

Henry Markram, Eilif Benjamin Muller, Ying Shi, Armando Romani, Felix Schürmann, Jean-Denis Georges Emile Courcol, Werner Alfons Hilda Van Geit, Christian Andreas Rössert, Maurizio Ferdinando Pezzoli, Michele Migliore

Every neuron is part of a network, exerting its function by transforming multiple spatiotemporal synaptic input patterns into a single spiking output. This function is specified by the particular shape and passive electrical properties of the neuronal memb ...

2018