Person
Sofia Tsouka
This person is no longer with EPFL
Related publications (7)
Constraint-based metabolic control analysis for rational strain engineering
Vassily Hatzimanikatis, Ljubisa Miskovic, Meriç Ataman, Tuure Eelis Hameri, Sofia Tsouka
The advancements in genome editing techniques over the past years have rekindled interest in rational metabolic engineering strategies. While Metabolic Control Analysis (MCA) is a well-established method for quantifying the effects of metabolic engineering ...
2021Mapping and Analysis of the Complexity of Lipid Metabolism for Applications in Health and Sustainability
Vassily Hatzimanikatis, Sofia Tsouka
Metabolism is a network of biotransformations that sustain life in cells. Over the past decades, metabolism has been studied in multiple contexts, ranging from medicine to industrial manufacturing. In particular, lipid metabolism has been linked to various ...
EPFL2020redLips: a comprehensive mechanistic model of the lipid metabolic network of yeast
Vassily Hatzimanikatis, Sofia Tsouka
Over the last decades, yeast has become a key model organism for the study of lipid biochemistry. Because the regulation of lipids has been closely linked to various physiopathologies, the study of these biomolecules could lead to new diagnostics and treat ...
OXFORD UNIV PRESS2020Mapping the diverse phenotypic states of yeast lipid metabolism to enzymes using mechanistic kinetic models
Lipids carry a very important role in cell structure and function, as well as in the physiopathology of many diseases. Maintenance of the lipid profiles should be tightly regulated as it is very important for preserving membrane permeability, cell integrit ...
2018Identification of the enzymes responsible for diverse phenotypic states of yeast lipid metabolism using comprehensive mechanistic models
Lipids carry an important role in cell structure and function, as well as in the physiopathology of multiple diseases. Maintenance of the lipid profiles should be tightly regulated for preserving membrane permeability, cell integrity and several other func ...
2018Identification of the enzymes that determine the robustness of lipid profiles in yeast
Vassily Hatzimanikatis, Howard Riezman, Georgios Savoglidis, Sofia Tsouka
Lipids play a very important role in cell structure and function, as well as in the physiopathology of many diseases. Maintenance of the lipid profiles should be tightly regulated as it is very important for preserving membrane permeability, cell integrity ...
2017A kinetic model of the lipid network in yeast
Vassily Hatzimanikatis, Georgios Savoglidis, Sofia Tsouka
Lipids play a very important role in cell structure and function, as well as in the physiopathology of many diseases. Maintenance of the lipid profiles should be tightly regulated as it is very important for preserving membrane permeability, cell integrity ...
2017