Publications by Augusto Martins Lima

Effect of the structural modification of Candesartan with Zinc on hypertension and left ventricular hypertrophy

Nikolaos Stergiopoulos, Augusto Martins Lima, Valeria Romina Martinez

Hypertension is the most common cause of left ventricular hypertrophy, contributing to heart failure progression. Candesartan (Cand) is an angiotensin receptor antagonist widely used for hypertension treatment. Structural modifications were previously perf ...

ELSEVIER2023

Apelin-13 Protects Corpus Cavernosum Against Fibrosis Induced by High-Fat Diet in an MMP-Dependent Mechanism

Nikolaos Stergiopoulos, Mikaël Nils Sturny, Rafaela Fernandes Da Silva, Augusto Martins Lima, Fabiana Pereira Da Costa Fraga, Maiia Bragina, Léa Liliane Colette Anguenot

Background: An increased fibrosis of the corpora cavernosa is a prevalent process that underlies most cases of erectile dysfunction. Apelin, an endogenous circulating peptide, has been documented as an important effector on cardiovascular homeostasis, cont ...

ELSEVIER SCI LTD2021

Zinc complexation improves angiotensin II receptor type 1 blockade and in vivo antihypertensive activity of telmisartan

Nikolaos Stergiopoulos, Augusto Martins Lima, Valeria Romina Martinez

Background: Angiotensin II receptor blockers were designed as therapeutic agents to block the binding site of the angiotensin II receptor type 1 (AT1R). Methodology: The structure of telmisartan was modified by coordination to the biometal Zn(II), resultin ...

FUTURE SCI LTD2021

Flow driven robotic navigation of microengineered endovascular probes

Nikolaos Stergiopoulos, Diego Ghezzi, Mahmut Selman Sakar, Augusto Martins Lima, Adele Fanelli, Lucio Feo Pancaldi-Giubbini, Pietro Luciano Jakobus Dirix

Minimally invasive medical procedures, such as endovascular catheterization, have considerably reduced procedure time and associated complications. However, many regions inside the body, such as in the brain vasculature, still remain inaccessible due to th ...

Nature Research2020

Standardization and Validation of Fluorescence-Based Quantitative Assay to Study Human Platelet Adhesion to Extracellular-Matrix in a 384-Well Plate

Nikolaos Stergiopoulos, Augusto Martins Lima, Tom Yohan Abraham Lachkar, François Cuenot, Cindy Marie Elodie Khawand, Damian Salim Saint Auguste

Platelets play a crucial role in the immunological response and are involved in the pathological settings of vascular diseases, and their adhesion to the extracellular matrix is important to bring leukocytes close to the endothelial cells and to form and s ...

2020

Dark Energy Survey Year 1 results: Methodology and projections for joint analysis of galaxy clustering, galaxy lensing, and CMB lensing two-point functions

Eduardo Sanchez, Jonathan Andrew Blazek, Augusto Martins Lima, César Octavio Domínguez Sánchez De La Blanca, Craig Matthew Smith

Optical imaging surveys measure both the galaxy density and the gravitational lensing-induced shear fields across the sky. Recently, the Dark Energy Survey (DES) Collaboration used a joint fit to two-point correlations between these observables to place ti ...

American Physical Society2019

From Patients to Platelets and Back Again: Pharmacological Approaches to Glycoprotein VI, a Thrilling Antithrombotic Target with Minor Bleeding Risks

Nikolaos Stergiopoulos, Augusto Martins Lima

Despite significant advances in the treatment of thrombogenic diseases, antiplatelet therapies are still associated with a high bleeding risk. Consequently, potential benefits of preventing thromboembolic events by pharmacological agents need to be balance ...

GEORG THIEME VERLAG KG2019

An optimized and validated 384-well plate assay to test platelet function in a high-throughput screening format

Nikolaos Stergiopoulos, Olivier Burri, Marc Chambon, Rodrigo Araujo Fraga Da Silva, Fabiana Pereira Da Costa Fraga, Julien Bortoli Chapalay, Augusto Martins Lima, Maiia Bragina

Despite significant advances in the treatment of cardiovascular diseases, antiplatelet therapies are still associated with a high risk of hemorrhage. In order to develop new drugs, methods to measure platelet function must be adapted for the high-throughpu ...

TAYLOR & FRANCIS INC2019

Atroxlysin-III, A Metalloproteinase from the Venom of the Peruvian Pit Viper Snake Bothrops atrox (Jergon) Induces Glycoprotein VI Shedding and Impairs Platelet Function

Augusto Martins Lima

Atroxlysin-III (Atr-III) was purified from the venom of Bothrops atrox. This 56-kDa protein bears N-linked glycoconjugates and is a P-III hemorrhagic metalloproteinase. Its cDNA-deduced amino acid sequence reveals a multidomain structure including a propro ...

2019

The Dark Energy Survey: Data Release 1

Eduardo Sanchez, Xin Chen, Vanda Carla Costa Grisel, Aaron James Rossini, Yi Zhang, Jonathan Andrew Blazek, Jennifer Kaitlyn Olsen, Xi Chen, Augusto Martins Lima, Juan Andrei Villarroel Fernandez

We describe the first public data release of the Dark Energy Survey, DES DR1, consisting of reduced single-epoch images, co-added images, co-added source catalogs, and associated products and services assembled over the first 3 yr of DES science operations ...

IOP PUBLISHING LTD2018