Publications by Omar Awile | EPFL Graph Search

A connectome manipulation framework for the systematic and reproducible study of structure–function relationships through simulations

Michael Reimann, Matthias Wolf, James Bryden Isbister, Omar Awile, Christoph Pokorny, Mustafa Kerem Kurban

Synaptic connectivity at the neuronal level is characterized by highly non-random features. Hypotheses about their role can be developed by correlating structural metrics to functional features. But to prove causation, manipulations of connectivity would h ...

2024

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King, Rajnish Ranjan, Armando Romani, Mustafa Anil Tuncel, Aleksandra Zuzanna Teska, Polina Litvak

Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study in vivo. Large-scale, biophysically detailed models offer a tool which can complement laboratory approaches. We present a m ...

2024

MOD2IR: High-Performance Code Generation for a Biophysically Detailed Neuronal Simulation DSL

Felix Schürmann, Pramod Shivaji Kumbhar, Omar Awile, Snehal Pramod Kumbhar, Ioannis Magkanaris

Advances in computational capabilities and large volumes of experimental data have established computer simulations of brain tissue models as an important pillar in modern neuroscience. Alongside, a variety of domain specific languages (DSLs) have been dev ...

ACM2023

Editorial: Neuroscience, computing, performance, and benchmarks: Why it matters to neuroscience how fast we can compute

Felix Schürmann, Omar Awile

2023

Modernizing the NEURON Simulator for Sustainability, Portability, and Performance

James Gonzalo King, Felix Schürmann, Pramod Shivaji Kumbhar, Omar Awile, Ioannis Magkanaris

The need for reproducible, credible, multiscale biological modeling has led to the development of standardized simulation platforms, such as the widely-used NEURON environment for computational neuroscience. Developing and maintaining NEURON over several d ...

2022

STEPS 4.0: Fast and memory-efficient molecular simulations of neurons at the nanoscale

Felix Schürmann, James Gonzalo King, Pramod Shivaji Kumbhar, Omar Awile, Christos Kotsalos, Tristan Mathieu Carel, Iain Hepburn, Samuel Marie A Melchior, Weiliang Chen, Baudouin Paul Michel Maria Joseph Del Marmol

Recent advances in computational neuroscience have demonstrated the usefulness and importance of stochastic, spatial reaction-diffusion simulations. However, ever increasing model complexity renders traditional serial solvers, as well as naive parallel imp ...

FRONTIERS MEDIA SA2022

An Optimizing Multi-platform Source-to-source Compiler Framework for the NEURON MODeling Language

Felix Schürmann, James Gonzalo King, Michael Lee Hines, Pramod Shivaji Kumbhar, Omar Awile, Jorge Blanco Alonso, Liam Roger George Keegan

Domain-specific languages (DSLs) play an increasingly important role in the generation of high performing software. They allow the user to exploit domain knowledge for the generation of more efficient code on target architectures. Here, we describe a new c ...

Springer2020

CoreNEURON: Performance and Energy Efficiency Evaluation on Intel and Arm CPUs

Omar Awile, Ioannis Magkanaris

The simulation of detailed neuronal circuits is based on computationally expensive software simulations and requires access to a large computing cluster. The appearance of new Instruction Set Architectures (ISAs) in most recent High-Performance Computing ( ...

IEEE COMPUTER SOC2020