Publications by Samuel Lieven D. Lapere

Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy

Henry Markram, Kathryn Hess Bellwald, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King, Lida Kanari, Ying Shi, Armando Romani, Adrien Michel Achille Devresse

The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, hierarchical, interregional structure with a highly specific laminar architecture. The last decade has seen the emergence of extensive new ...

2024

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King, Rajnish Ranjan, Armando Romani, Mustafa Anil Tuncel, Aleksandra Zuzanna Teska, Polina Litvak

Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study in vivo. Large-scale, biophysically detailed models offer a tool which can complement laboratory approaches. We present a m ...

2024

Metaball skinning of synthetic astroglial morphologies into realistic mesh models for visual analytics and in silico simulations

Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jay Coggan, Samuel Lieven D. Lapere, Nadir Roman Guerrero, Alessandro Enrico Foni, Eleftherios Zisis

Motivation: Astrocytes, the most abundant glial cells in the mammalian brain, have an instrumental role in developing neuronal circuits. They contribute to the physical structuring of the brain, modulating synaptic activity and maintaining the blood-brain ...

OXFORD UNIV PRESS2021

Interactive visualization and analysis of morphological skeletons of brain vasculature networks with VessMorphoVis

Henry Markram, Felix Schürmann, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Jean-Denis Georges Emile Courcol, Jay Coggan, Samuel Lieven D. Lapere, Nadir Roman Guerrero, Benoît Jean-Albert Coste

Motivation: Accurate morphological models of brain vasculature are key to modeling and simulating cerebral blood flow in realistic vascular networks. This in silico approach is fundamental to revealing the principles of neurovascular coupling. Validating t ...

OXFORD UNIV PRESS2020

Generating High Fidelity Surface Meshes of Neocortical Neurons using Skin Modifiers

Felix Schürmann, Marwan Muhammad Ahmed Abdellah, Juan Bautista Hernando Vieites, Cyrille Pierre Henri Favreau, Samuel Lieven D. Lapere

We present the results of exploring the capabilities of skinning modifiers to generate high fidelity polygonal surface meshes of neurons from their morphological skeletons that are segmented from optical microscopy slides. Our algorithm is implemented in B ...

2019

High Fidelity Visualization of Large Scale Digitally Reconstructed Brain Circuitry with Signed Distance Functions

Felix Schürmann, Marwan Muhammad Ahmed Abdellah, Sébastien Nicolas Speierer, Samuel Lieven D. Lapere, Alessandro Enrico Foni, Jonas Kristofer Karlsson

We explore a first proof-of-concept application for visualizing large scale digitally reconstructed brain circuitry using signed distance functions. The significance of our method is demonstrated in comparison with using implicit geometry that is limited t ...

IEEE2019