Publications by Jean-David Horacio Morel

Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway

Johan Auwerx, Alessia Perino, Adrienne Joëlle Laurence Mottis, Jean-David Horacio Morel

Nori is a component of the traditional Japanese diet. The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori t ...

2025

Systems genetics of metabolic health in the BXD mouse genetic reference population

Johan Auwerx, Xiaoxu Li, Jia Liu, Maroun Bou Sleiman, Wen Gao, Amélia Lalou, Alessia De Masi, Jean-David Horacio Morel

Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate genetic var ...

2024

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Johan Auwerx, Laurent Mouchiroud, Xiaoxu Li, Maroun Bou Sleiman, Elena Katsyuba, Wen Gao, Yang Li, Amélia Lalou, Gaby El Alam, Jean-David Horacio Morel

Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determinants in 85 C. e ...

2024

Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia

Johan Auwerx, Tanes Imamura de Lima, Sandra Rodriguez Lopez, Alessia De Masi, Jean-David Horacio Morel

The accumulation of ceramides and related metabolites has emerged as a pivotal mechanism contributing to the onset of age-related diseases. However, small molecule inhibitors targeting the ceramide de novo synthesis pathway for clinical use are currently u ...

2024

Sodium ferrous citrate and 5-aminolevulinic acid improve type 2 diabetes by maintaining muscle and mitochondrial health

Johan Auwerx, Jean-David Horacio Morel

ObjectiveImproving mitochondrial function is a promising strategy for intervention in type 2 diabetes mellitus. This study investigated the preventive effects of sodium ferrous citrate (SFC) and 5-aminolevulinic acid phosphate (ALA) on several metabolic dy ...

WILEY2023

The genetic background shapes the susceptibility to mitochondrial dysfunction and NASH progression

Johan Auwerx, Sandra Rodriguez Lopez, Giacomo Vincenzo Giorgio Von Alvensleben, Maroun Bou Sleiman, Ludger Jan Elzuë Goeminne, Alexis Maximilien Bachmann, Jean-David Horacio Morel

Mice from different genetic backgrounds have widely diverse responses to the same metabolic challenges. Only PWK/PhJ mice show significant mitochondrial dysfunction and progression to fibrotic NASH that resembles human NASH. The PWK/PhJ strain is a novel N ...

ROCKEFELLER UNIV PRESS2023

Learning from the past: A short term forecast method for the COVID-19 incidence curve

Jean-David Horacio Morel

Author summaryForecasting the short time evolution of the COVID-19 daily incidence is a key issue in the epidemic decision making policy. We propose a machine learning method which forecasts the future values of the daily incidence trend based on the evolu ...

PUBLIC LIBRARY SCIENCE2023

Inhibiting de novo ceramide synthesis restores mitochondrial and protein homeostasis in muscle aging

Johan Auwerx, Xiaoxu Li, Mario Romani, Tanes Imamura de Lima, Sandra Rodriguez Lopez, Hao Li, Martin Rainer Wohlwend, Pirkka-Pekka Untamo Laurila, Ludger Jan Elzuë Goeminne, Dohyun Park

Disruption of mitochondrial function and protein homeostasis plays a central role in aging. However, how these processes interact and what governs their failure in aging remain poorly understood. Here, we showed that cer- amide biosynthesis controls the de ...

AMER ASSOC ADVANCEMENT SCIENCE2023

Time warping between main epidemic time series in epidemiological surveillance

Jean-David Horacio Morel

The most common reported epidemic time series in epidemiological surveillance are the daily or weekly incidence of new cases, the hospital admission count, the ICU admission count, and the death toll, which played such a prominent role in the struggle to m ...

Public Library Science2023

Mitochondrial and NAD plus metabolism predict recovery from acute kidney injury in a diverse mouse population

Johan Auwerx, Giacomo Vincenzo Giorgio Von Alvensleben, Maroun Bou Sleiman, Dina Hofer, Yang Li, Alexis Maximilien Bachmann, Jean-David Horacio Morel

Acute kidney failure and chronic kidney disease are global health issues steadily rising in incidence and prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. Here, we ...

AMER SOC CLINICAL INVESTIGATION INC2023