Publications by Amélia Lalou | EPFL Graph Search

A lysosomal surveillance response to stress extends healthspan

Johan Auwerx, Xiaoxu Li, Tanes Imamura de Lima, Jia Liu, Qi Wang, Wen Gao, Yang Li, Amélia Lalou

Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal ...

Springer Science and Business Media LLC2025

Systems genetics of metabolic health in the BXD mouse genetic reference population

Johan Auwerx, Xiaoxu Li, Jia Liu, Maroun Bou Sleiman, Wen Gao, Amélia Lalou, Alessia De Masi, Jean-David Horacio Morel

Susceptibility to metabolic syndrome (MetS) is dependent on genetics, environment, and gene-by-environment interactions, rendering the study of underlying mechanisms challenging. The majority of experiments in model organisms do not incorporate genetic var ...

2024

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Johan Auwerx, Laurent Mouchiroud, Xiaoxu Li, Maroun Bou Sleiman, Elena Katsyuba, Wen Gao, Yang Li, Amélia Lalou, Gaby El Alam, Jean-David Horacio Morel

Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determinants in 85 C. e ...

2024

Drug Screening in C. elegans to identify new pharmacological mitochondrial stress inducers

Amélia Lalou

Mitochondria are essential organelles participating in numerous cellular functions, including energy harvesting, regulation of homeostasis and apoptosis. Changes in mitochondrial number, morphology, and function not only impact cellular metabolism but also ...

EPFL2024

Inhibition of CERS1 in skeletal muscle exacerbates age-related muscle dysfunction

Johan Auwerx, Olivier Burri, Xiaoxu Li, Tanes Imamura de Lima, Giacomo Vincenzo Giorgio Von Alvensleben, Martin Rainer Wohlwend, Pirkka-Pekka Untamo Laurila, Ludger Jan Elzuë Goeminne, Amélia Lalou, Barbara Moreira Crisol

Age-related muscle wasting and dysfunction render the elderly population vulnerable and incapacitated, while underlying mechanisms are poorly understood. Here, we implicate the CERS1 enzyme of the de novo sphingolipid synthesis pathway in the pathogenesis ...

2023

Article Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

Johan Auwerx, Maroun Bou Sleiman, Wen Gao, Yang Li, Amélia Lalou, Gaby El Alam

The mitochondrial unfolded protein response (UPRmt) is a promising pharmacological target for aging and age-related diseases. However, the integrative analysis of the impact of UPRmt activation on different signaling layers in animals with different geneti ...

CELL PRESS2022

V-ATPase/TORC1-mediated ATFS-1 translation directs mitochondrial UPR activation in C. elegans

Johan Auwerx, Kristina Schoonjans, Felix Naef, Xiaoxu Li, Jia Liu, Hao Li, Wen Gao, Nagammal Neelagandan, Yang Li, Amélia Lalou

To adapt mitochondrial function to the ever-changing intra- and extracellular environment, multiple mitochondrial stress response (MSR) pathways, including the mitochondrial unfolded protein response (UPRmt), have evolved. However, how the mitochondrial st ...

Rockefeller University Press2022