Publications by Darshan Mandge

A multiscale electro-metabolic model of a rat neocortical circuit reveals the impact of ageing on central cortical layers

Henry Markram, James Gonzalo King, Daniel Keller, James Bryden Isbister, Polina Shichkova, Darshan Mandge, Alessandro Cattabiani

The high energetic demands of the brain arise primarily from neuronal activity. Neurons consume substantial energy to transmit information as electrical signals and maintain their resting membrane potential. These energetic requirements are met by the neur ...

Public Library of Science (PLoS)2025

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

Henry Markram, Werner Alfons Hilda Van Geit, Tanguy Pierre Louis Damart, Darshan Mandge, Mickael Maurice Zbili, Aurélien Tristan Jaquier

In computational neuroscience, multicompartment models are among the most biophysically realistic representations of single neurons. Constructing such models usually involves the use of the patch-clamp technique to record somatic voltage signals under diff ...

2024

Modeling and simulation of neocortical micro- and mesocircuitry. Part II: Physiology and experimentation

Henry Markram, Eilif Benjamin Muller, Srikanth Ramaswamy, Michael Reimann, James Gonzalo King, Rajnish Ranjan, Armando Romani, Mustafa Anil Tuncel, Aleksandra Zuzanna Teska, Polina Litvak

Cortical dynamics underlie many cognitive processes and emerge from complex multi-scale interactions, which are challenging to study in vivo. Large-scale, biophysically detailed models offer a tool which can complement laboratory approaches. We present a m ...

2024

BlueCelluLab: Biologically Detailed Neural Network Experimentation API

Henry Markram, Eilif Benjamin Muller, Lida Kanari, Mustafa Anil Tuncel, Werner Alfons Hilda Van Geit, Darshan Mandge, Aurélien Tristan Jaquier

The NEURON simulator, established in 1984 and continuously developed since, stands as the preeminent tool for neuron simulation within computational neuroscience. Its widespread adoption and compatibility with computational clusters and supercomputers unde ...

The Open Journal2024

A universal workflow for creation, validation and generalization of detailed neuronal models

Henry Markram, Srikanth Ramaswamy, Mustafa Anil Tuncel, Werner Alfons Hilda Van Geit, Alexis Arnaudon, Christian Andreas Rössert, Maria Reva, Tanguy Pierre Louis Damart, Darshan Mandge

Detailed single neuron modeling is widely used to study neuronal functions. While cellular and functional diversity across the mammalian cortex is vast, most of the available computational tools are dedicated to the reproduction of a small set of specific ...

Cambridge2023