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Simone Romeni

Related publications (11)

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A method for optimizing at least one of a geometry, an implantation procedure, and/or stimulation protocol of one or more electrodes for an electrical stimulation of a target structure in a nervous system of a living being by a computer device, the method ...

2024

Biophysically accurate and machine learning-based surrogate models to optimize neuroprosthesis design and operation

Simone Romeni

Electrical stimulation of the nervous system has emerged as a promising assistive technology in case of many injuries and illnesses across various parts of the nervous system. In particular, the invasive neuromodulation of the peripheral nervous system see ...

EPFL2024

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Electrical stimulation of the visual nervous system could improve the quality of life of patients affected by acquired blindness by restoring some visual sensations, but requires careful optimization of stimulation parameters to produce useful perceptions. ...

Aip Publishing2024

Combining biophysical models and machine learning to optimize implant geometry and stimulation protocol for intraneural electrodes

Silvestro Micera, Simone Romeni, Elena Losanno, Luca Pierantoni

Objective. Peripheral nerve interfaces have the potential to restore sensory, motor, and visceral functions. In particular, intraneural interfaces allow targeting deep neural structures with high selectivity, even if their performance strongly depends upon ...

IOP Publishing Ltd2023

Reconstruction of nerve functional topography using recruitment curves enables selective electrical stimulation

Silvestro Micera, Simone Romeni, Bianca Ziliotto

Multi-polar stimulation protocols have been used in the past to increase the selectivity of electrical stimulation of the nervous system. Nonetheless, the number of possible multipolar stimulation protocols is prohibitively large and cannot be explored dur ...

IEEE2023

Machine-learning predictor of nerve fiber firing rate allows the automatic optimization of electrical stimulation protocols

Silvestro Micera, Simone Romeni, Luca Pierantoni, Gabriele Marino

Computational models have been widely employed to study the electrical stimulation of the nervous system. Still, most applications either study fundamental mechanisms underlying stimulation, or address qualitative scientific questions. When quantitative qu ...

IEEE2023

A method to establish functional vagus nerve topography from electro-neurographic spontaneous activity

Silvestro Micera, Simone Romeni

Bioelectronic medicine is an emerging approach to treat many types of diseases via electrical stimulation of the autonomic nervous system (ANS). Because the vagus nerve (VN) is one of the most important nerves controlling several ANS functions, stimulation ...

2022

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Objective. Bioelectronic medicine is opening new perspectives for the treatment of some major chronic diseases through the physical modulation of autonomic nervous system activity. Being the main peripheral route for electrical signals between central nerv ...

IOP PUBLISHING LTD2021

Providing a naturalistic tactile sensory feedback is currently one of the key challenges in neuroprosthetics. Modeling has played a fundamental role in the development of "biomimetic" stimulation protocols, determining optimal activation patterns to be eli ...

IEEE2021

Tutorial: a computational framework for the design and optimization of peripheral neural interfaces

Silvestro Micera, Simone Romeni, Giacomo Valle

Peripheral neural interfaces have been successfully used in the recent past to restore sensory-motor functions in disabled subjects and for the neuromodulation of the autonomic nervous system. The optimization of these neural interfaces is crucial for ethi ...

NATURE RESEARCH2020