Publications by Michael Alan Wayne

Beneath the surface: revealing deep-tissue blood flow in human subjects with massively parallelized diffuse correlation spectroscopy

Edoardo Charbon, Claudio Bruschini, Arin Can Ülkü, Michael Alan Wayne

Significance: Diffuse correlation spectroscopy (DCS) allows label-free, non-invasive investigation of microvascular dynamics deep within tissue, such as cerebral blood flow (CBF). However, the signal-to-noise ratio (SNR) in DCS limits its effective cerebra ...

SPIE-Intl Soc Optical Eng2025

Massively multiplexed wide-field photon correlation sensing

Edoardo Charbon, Claudio Bruschini, Michael Alan Wayne

Temporal photon correlations have been a crucial resource for quantum and quantum-enabled optical science for over half a century. However, attaining non-classical information through these correlations has typically been limited to a single point (or, at ...

2025

Deep blood flow extraction for diffuse correlation spectroscopy at photon-starved regimes using SPAD arrays

Edoardo Charbon, Claudio Bruschini, Michael Alan Wayne

Diffuse correlation spectroscopy (DCS) is an optical technique that allows for non-invasive measurements of tissue perfusion, and is often used for neuromonitoring applications. However, a major challenge of DCS is low SNR for deep tissue measurements. Rec ...

2024

Piccolo gated: a CMOS 32×32 SPAD camera with all-solid-state nanosecond time gating and PCIe readout for single-photon time-domain DCS and near-infrared optical tomography

Edoardo Charbon, Claudio Bruschini, Paul Mos, Tommaso Milanese, Scott Anthony Lindner, Michael Alan Wayne

The Piccolo gated sensor features a 32x32 SPAD array of single-photon avalanche diodes (SPADs) operating in time-correlated single-photon counting (TCSPC). The chip enables event-driven readout and a maximum count rate of 220 Mcps. The sensor is based on t ...

SPIE2024

Demonstration of particle tracking with scintillating fibres read out by a SPAD array sensor and application as a neutrino active target

Edoardo Charbon, Claudio Bruschini, Paul Mos, Kodai Kaneyasu, Michael Alan Wayne

Scintillating fibre detectors combine sub-mm resolution particle tracking, precise measurements of the particle stopping power and sub-ns time resolution. Typically, fibres are read out with silicon photomultipliers (SiPM). Hence, if fibres with a few hund ...

Springer2024

GPU-based data processing for speeding-up correlation plenoptic imaging

Edoardo Charbon, Claudio Bruschini, Paul Mos, Samuel Burri, Arin Can Ülkü, Michael Alan Wayne

Correlation plenoptic imaging (CPI) is a novel technological imaging modality enabling to overcome drawbacks of standard plenoptic devices, while preserving their advantages. However, a major challenge in view of real-time application of CPI is related to ...

2024

Towards Surface-Correction of Deep-Tissue Blood Flow Dynamics with Massively Parallelized Diffuse Correlation Spectroscopy

Edoardo Charbon, Claudio Bruschini, Michael Alan Wayne

Diffuse Correlation Spectroscopy (DCS) allows the optical and label-free investigation of microvascular dynamics. Commonly, DCS is implemented with highly sensitive and ultra fast single-photon avalanche diodes (SPAD) for blood flow measurements from aroun ...

SPIE2024

Efficient signal extraction for diffuse correlation spectroscopy with SPAD arrays at low photon regimes

Edoardo Charbon, Claudio Bruschini, Michael Alan Wayne

SPAD arrays have shown potential for improving SNR for diffuse correlation spectroscopy in low photon regimes. Here, we will explore different methods of integrating parallelized DCS signals in such regimes for deep blood flow extraction. ...

Optical Society of America2024

Quantum ghost imaging microscopy depth-of-field study

Edoardo Charbon, Claudio Bruschini, Paul Mos, Yang Lin, Michael Alan Wayne

Quantum ghost imaging approaches have been proposed to enhance biological microscopy, for example, using 2D visible detectors to provide IR images or providing additional dimensions of spatial or spectral information. Toward the goal of making such imaging ...

2024

Towards precise optical measurements of steady state of and small changes in resting membrane potentials

Edoardo Charbon, Claudio Bruschini, Michael Alan Wayne

CELL PRESS2023