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Nako Nakatsuka

Related publications (32)

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Phenylalanine Monitoring via Aptamer-Field-Effect Transistor Sensors

Nako Nakatsuka

Determination of the amino acid phenylalanine is important for lifelong disease management in patients with phenylketonuria, a genetic disorder in which phenylalanine accumulates and persists at levels that alter brain development and cause permanent neuro ...

2019

Hierarchically Patterned Polydopamine-Containing Membranes for Periodontal Tissue Engineering

Nako Nakatsuka, Song Li

Periodontitis is a common chronic inflammatory disease that affects tooth-supporting tissues. We engineer a multifunctional periodontal membrane for the guided tissue regeneration of lost periodontal tissues. The major drawback of current periodontal membr ...

2019

Aptamer–field-effect transistors overcome Debye length limitations for small-molecule sensing

Nako Nakatsuka, Yang Yang, Bowen Zhu

Detection of analytes by means of field-effect transistors bearing ligand-specific receptors is fundamentally limited by the shielding created by the electrical double layer (the “Debye length” limitation). We detected small molecules under physiological h ...

2018

Aptamers are chemically synthesized oligonucleotides or peptides with molecular recognition capabilities. We investigated recognition of substrate-tethered small-molecule targets, using neurotransmitters as examples, and fluorescently labeled DNA aptamers. ...

2018

Polyserotonin Nanoparticles as Multifunctional Materials for Biomedical Applications

Nako Nakatsuka

Serotonin-based nanoparticles represent a class of previously unexplored multifunctional nanoplatforms with potential biomedical applications. Serotonin, under basic conditions, self-assembles into monodisperse nanoparticles via autoxidation of serotonin m ...

2018

Small-Molecule Patterning via Prefunctionalized Alkanethiols

Nako Nakatsuka

Interactions between small molecules and biomolecules are important physiologically and for biosensing, diagnostic, and therapeutic applications. To investigate these interactions, small molecules can be tethered to substrates through standard coupling che ...

2018

High-Affinity Nucleic-Acid-Based Receptors for Steroids

Nako Nakatsuka, Yameng Zhang

Artificial receptors for hydrophobic molecules usually have moderate affinities and limited selectivities. We describe three new classes of high affinity hydrophobic receptors for nonaromatic steroids based on deoxyribonucleotides, obtained through five hi ...

2017

Creating small-molecule-functionalized platforms for high-throughput screening or biosensing applications requires precise placement of probes on solid substrates and the ability to capture and to sort targets from multicomponent samples. Here, chemical li ...

2017

Understanding spin-selective interactions between electrons and chiral molecules is critical to elucidating the significance of electron spin in biological processes and to assessing the potential of chiral assemblies for organic spintronics applications. ...

2017

Monitoring dopamine and norepinephrine (or other structurally similar neurotransmitters) in the same brain region necessitates selective sensing. In this Viewpoint, we highlight electrochemical and optical strategies for advancing simultaneous real-time me ...

2017