Ambulatory arterial stiffness index does not accurately assess arterial stiffness

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Novel theory and potential applications of central diastolic pressure decay time constant

Nikolaos Stergiopoulos, Georgios Rovas, Sokratis Anagnostopoulos, Vasiliki Bikia, Patrick Segers

Central aortic diastolic pressure decay time constant ( ) is according to the two-element Windkessel model equal to the product of total peripheral resistance (R) times total arterial compliance (C ). As such, it is related to arterial stiffness, which has ...

2024

Compliance-matching vascular grafts with personalization potential

Georgios Rovas

Aortic diseases are characterized by dire prognosis and inadequate diagnosis, owing to their insidious yet lethal nature. Aortopathies, namely aortic aneurysms and dissections, along with certain congenital diseases, might necessitate surgical replacement ...

EPFL2023

Modulation of Pulsatile Left Ventricular Afterload by Renal Denervation in Heart Failure With Preserved Ejection Fraction

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou

Background:Arterial stiffening contributes to hemodynamic derangements in heart failure with preserved ejection fraction (HFpEF). We sought to investigate the impact of renal denervation on pulsatile left ventricular loading in patients with HFpEF and hype ...

Lippincott Williams & Wilkins2023

On the similarity between aortic and carotid pressure diastolic decay: a mathematical modelling study

Nikolaos Stergiopoulos, Georgios Rovas, Sokratis Anagnostopoulos, Vasiliki Bikia

Aortic diastolic pressure decay (DPD) has been shown to have considerable pathophysiological relevance in the assessment of vascular health, as it is significantly affected by arterial stiffening. Nonetheless, the aortic pressure waveform is rarely availab ...

Nature Portfolio2023

Arterial pulse wave modeling and analysis for vascular-age studies: a review from VascAgeNet

Vasiliki Bikia, Patrick Segers

Arterial pulse waves (PWs) such as blood pressure and photoplethysmogram (PPG) signals contain a wealth of information on the cardiovascular (CV) system that can be exploited to assess vascular age and identify individuals at elevated CV risk. We review th ...

AMER PHYSIOLOGICAL SOC2023

Causal inference with recurrent and competing events

Matias Janvin, Mats Julius Stensrud, Pal Christie Ryalen

Many research questions concern treatment effects on outcomes that can recur several times in the same individual. For example, medical researchers are interested in treatment effects on hospitalizations in heart failure patients and sports injuries in ath ...

SPRINGER2023

Design and computational optimization of compliance-matching aortic grafts

Nikolaos Stergiopoulos, Georgios Rovas, Vasiliki Bikia

Introduction: Synthetic vascular grafts have been widely used in clinical practice for aortic replacement surgery. Despite their high rates of surgical success, they remain significantly less compliant than the native aorta, resulting in a phenomenon calle ...

FRONTIERS MEDIA SA2023

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

Grégoire Courtine, Quentin Barraud, Jordan Squair, Matthieu Pierre Gautier, Victor Perez Puchalt, Loïs Thomas Romain Mahe, Rémi Bernard René Hudelle, Jan Elaine Cuevas Soriano, Suje Amir

Neurological disorders, including spinal cord injury, result in hemodynamic instability due to the disruption of supraspinal projections to the sympathetic circuits located in the spinal cord. We recently developed a preclinical model that allows the ident ...

NATURE PORTFOLIO2022

p-Aminobenzamidine attenuates cardiovascular dysfunctions in spontaneously hypertensive rats

Nikolaos Stergiopoulos, Fabiana Pereira Da Costa Fraga, Allancer Divino De Carvalho Nunes

Aims:Diminazene aceturate, a putative ACE2 activator, is susceptible to cleavage resulting in the formation of paminobenzamidine (PAB). This study aimed to investigate the effects of PAB in addressing cardiovascular dysfunctions in spontaneously hypertensi ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Cardiovascular monitoring system

Marco Mattavelli, Catherine Dehollain, Diego Ruben Barrettino, Kerim Türe, Mustafa Besirli

A cardiovascular monitoring system for measuring at least cardiac output comprises an implantable unit (2) configured for placement in a section of artery of a patient and a portable external unit (1) configured for mounting against or close to a patient's ...

2022

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