Publications related to Critical role of endothelial Notch1 signaling in postnatal angiogenesis

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

Georges Wagnières, Jaroslava Joniová, Séverine Marguerite Urfer

Therapies to accelerate vascular repair are currently lacking. Pre-clinical studies suggest that hydrogen sulfide (H2S), an endogenous gasotransmitter, promotes angiogenesis. Here, we hypothesized that sodium thiosulfate (STS), a clinically relevant source ...

FRONTIERS MEDIA SA2022

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Matthias Lütolf, Jeffrey Alan Hubbell, Yoji Tabata, Jun Ishihara, Kazuto Fukunaga

During wound healing, the distribution, availability, and signaling of growth factors (GFs) are orchestrated by their binding to extracellular matrix components in the wound microenvironment. Extracellular matrix proteins have been shown to modulate angiog ...

AMER SOC HEMATOLOGY2019

Microenvironmental regulation of tumour angiogenesis

Michele De Palma, Daniela Biziato

Tumours display considerable variation in the patterning and properties of angiogenic blood vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming of neoplastic tissue is a multidimensional process regulated by cancer cel ...

Nature Publishing Group2017

Design principles for therapeutic angiogenic materials

Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez

Despite extensive research, pro-angiogenic drugs have failed to translate clinically, and therapeutic angiogenesis, which has potential in the treatment of various cardiovascular diseases, remains a major challenge. Physiologically, angiogenesis - the proc ...

Nature Publishing Group2016

Vascular Modulatory Functions of Macrophages

Michele De Palma, Ioanna Keklikoglou

Monocytes/macrophages have long been regarded as important regulators of angiogenesis and vascular remodeling in both developmental and pathological processes. Historically, the ability of macrophages to promote vascular growth has been primarily attribute ...

Springer2014

Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF(164)

Veronica Sacchi, Jeffrey Alan Hubbell, Mikaël Martino, Kristen Lorentz, Martin Ehrbar, Elena Groppa

Clinical trials of therapeutic angiogenesis by vascular endothelial growth factor (VEGF) gene delivery failed to show efficacy. Major challenges include the need to precisely control in vivo distribution of growth factor dose and duration of expression. Re ...

Natl Acad Sciences2014

Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade

Michele De Palma, Céline Wyser Rmili, Ioanna Keklikoglou, Ece Kadioglu, Nicolo Rigamonti

Angiopoietin-2 (ANG2/ANGPT2) is a context-dependent TIE2 receptor agonist/antagonist and proangiogenic factor. Although ANG2 neutralization improves tumor angiogenesis and growth inhibition by vascular endothelial growth factor (VEGF)-A signaling blockade, ...

Elsevier2014

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino

Synergy in the downstream signaling pathways of the vascular endothelial growth factor receptor-2 (VEGFR-2) and the integrin alpha v beta 3 is critical for blood vessel formation. Thus, agents that activate both receptors could possess efficient pro-angiog ...

Elsevier2013

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Critical role of endothelial Notch1 signaling in postnatal angiogenesis

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Microenvironmental regulation of tumour angiogenesis

Identification and functional characterization of protein kinases that modulate Notch signaling under physiological conditions and in cancer

Design principles for therapeutic angiogenic materials

Vascular Modulatory Functions of Macrophages

Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF(164)

Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)

Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1

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Chat with Graph Search

Microenvironmental regulation of tumour angiogenesis

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Sodium thiosulfate, a source of hydrogen sulfide, stimulates endothelial cell proliferation and neovascularization

Identification and functional characterization of protein kinases that modulate Notch signaling under physiological conditions and in cancer

Tumor angiogenesis is enforced by autocrine regulation of high-mobility group box 1

Design principles for therapeutic angiogenic materials

Long-lasting fibrin matrices ensure stable and functional angiogenesis by highly tunable, sustained delivery of recombinant VEGF(164)

Vascular Modulatory Functions of Macrophages

Role of angiopoietin-2 in adaptive tumor resistance to VEGF signaling blockade

The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A(165)