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Understanding how small molecules interact with DNA is essential since it underlies a multitude of pathological conditions and therapeutic interventions. Many different intercalator compounds have been studied because of their activity as mutagens or drugs ...
Massive skeletons of living hypercalcified sponges, representative organisms of basal Metazoa, are uncommon models to improve our knowledge on biomineralization mechanisms and their possible evolution through time. Eight living species belonging to various ...
Electron crystallography is used to study membrane proteins in the form of planar, two-dimensional (2D) crystals, or other crystalline arrays such as tubular crystals. This method has been used to determine the atomic resolution structures of bacteriorhodo ...
In bulk composite materials, interfaces between adjacent materials can be neglected when evaluating the individual functional properties on the macroscopic scale. However, in nanostructured materials, what is described as an interfacial region can be a sig ...
CitS from Klebsiella pneumoniae acts as a secondary symporter of citrate and sodium ions across the inner membrane of the host. The protein is the best characterized member of the 2-hydroxycarboxylate transporter family, while no experimental structural in ...
Electron crystallography of 2D protein crystals provides a powerful tool for the determination of membrane protein structure. In this method, data is acquired in the Fourier domain as randomly sampled, uncoupled, amplitudes and phases. Due to physical cons ...
Electron crystallography of 2D protein crystals can determine the structure of membrane embedded proteins at high resolution. Images or electron diffraction patterns are recorded with the electron microscope of the frozen hydrated samples, and the 3D struc ...
Ultrashort pulses from x-ray free-electron laser (XFEL) sources promise to assist in obtaining the structures of membrane proteins at high resolution. We have reconstructed the electron density distribution of a two-dimensional (2D) aquaporin crystal from ...
Photoswitchable fluorescent proteins have enabled new approaches for imaging cells, but their utility has been limited either because they cannot be switched repeatedly or because the wavelengths for switching and fluorescence imaging are strictly coupled. ...
Electron crystallography is a powerful technique for the structure determination of membrane proteins as well as soluble proteins. Sample preparation for 2D membrane protein crystals is a crucial step, as proteins have to be prepared for electron microscop ...
