RGD-Functionalized polymer brushes as substrates for the integrin specific adhesion of human umbilical vein endothelial cells
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A review. The ubiquitous use of poly(ethylene glycol) in the biomaterials field has also boosted the research activity in the chem. derivatization of this polymer. We focused our interest on the prepn. of tailor-made poly(ethylene glycol)-based structures ...
We present a new type of microinstrument allowing manipulation and mechanical perturbation of individual cells under an optical microscope. These instruments, which we call microplates, are pulled from rectangular glass bars. They have flat tips, typically ...
Photopolymerized crosslinked networks of poly(ethylene glycol; PEG) diacrylate (MW 8000) were derivitized throughout their bulk with Arg-Gly-Asp (RGD)-containing peptide sequences. Incorporation was achieved by functionalizing the amine terminus of the pep ...
Postsurgical adhesions represent a common complication following a variety of surgical procedures. We sought to develop and evaluate a water-soluble polymer that could self-assemble onto tissue surfaces, forming a barrier on the surface. A copolymer was sy ...
Osteoblasts exhibit a more differentiated morphol. on surfaces with rough microtopogs. Surface effects are often mediated through integrins that bind the RGD motif in cell attachment proteins. Here, we tested the hypothesis that modulating access to RGD bi ...
The ability of the biomimetic peptides YIGSR, PHSRN and RGD to selectively affect adhesion and migration of human microvascular endothelial cells (MVEC) and vascular smooth muscle cells (HVSMC) was evaluated. Cell mobility was quantified by time-lapse vide ...
OBJECTIVES: Tissue engineering methods can be applied to regenerate diseased, or congenitally missing, urinary tract tissues. Urinary tract tissue cell cultures must be established in vitro and adequate matrices, acting as cell carriers, must be developed. ...
In tissue engineering, degradable or non-degradable polymer matrices can act as cell-carrier-scaffolds. Cell adhesion and growth on these scaffolds can be promoted by immobilizing extracellular matrix proteins. Therefore, in this study, polymer poly(ethyle ...
Methods for functionalising polymers for tissue engineering are disclosed in which a polymer matrix is activated to bind to biological materials such as cells by covalently bonding a hydrophilic polymer to carboxy groups of a polymer matrix. The hydrophili ...
A symposium report. A novel chem. approach for the synthesis of biotinylated glycosulfopeptides uses two different chemoselective ligation reactions in the presence of the sulfate moiety. The strategy was applied to the synthesis of a peptide sequence deri ...