Variable region cDNA sequences and characterization of murine anti-human interferon gamma receptor monoclonal antibodies that inhibit receptor binding by interferon gamma
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American Association for the Advancement of Science (AAAS)2019
We and others have previously observed that the antiviral effects of autocrine interferon (IFN)-alpha/beta activity cannot be abolished by neutralizing antibodies, even when present to a large excess. This raises the possibility that the major part of auto ...
Functionally active gamma interferon (IFN-gamma) receptors consist of an alpha subunit required for ligand binding uction and a beta subunit required primarily for signaling. Although the receptor alpha chain has little is known about the specific role of ...
The extracellular interferon gamma receptor alpha-chain (IFN gamma R) is believed to comprise two discrete approximately 110 amino acid immunoglobulin-like domains, perhaps similar to those seen in the crystal structure of the extracellular human growth ho ...
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