Publications related to N-Acetoxy-acetylaminofluorene reacts preferentially with a control region of intracellular SV40 chromosome

Statistical learning quantifies transposable element-mediated cis-regulation

Didier Trono, Evaristo Jose Planet Letschert, Julien Léonard Duc, Alexandre Coudray, Julien Paul André Pontis, Delphine Yvette L Grun, Cyril David Son-Tuyên Pulver, Shaoline Sheppard

Background: Transposable elements (TEs) have colonized the genomes of most metazoans, and many TE-embedded sequences function as cis-regulatory elements (CREs) for genes involved in a wide range of biological processes from early embryo- genesis to innate ...

2023

Chromatin modules and their implication in genomic organization and gene regulation

Bart Deplancke, Guido Van Mierlo, Judith Franziska Kribelbauer

Regulation of gene expression is a complex but highly guided process. While genomic technologies and computational approaches have allowed high-throughput mapping of cis-regulatory elements (CREs) and their interactions in 3D, their precise role in regulat ...

ELSEVIER SCIENCE LONDON2023

Chromatin Proteomics to Study Epigenetics - Challenges and Opportunities

Guido Van Mierlo

Regulation of gene expression is essential for the functioning of all eukaryotic organisms. Understanding gene expression regulation requires determining which proteins interact with regulatory elements in chromatin. MS-based analysis of chromatin has emer ...

AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC2021

Induction of a chromatin boundary in vivo upon insertion of a tad border

Denis Duboule, Lucille Delisle, Christopher Chase Bolt, Edgardo Rodriguez Carballo, Marie-Laure Gadolini

Author summary During development, enhancer sequences tightly regulate the spatio-temporal expression of target genes often located hundreds of kilobases away. This complex process is made possible by the folding of chromatin into domains, which are separa ...

PUBLIC LIBRARY SCIENCE2021

Chromatin three-dimensional interactions mediate genetic effects on gene expression

David Hacker, Giovanna Ambrosini, Philipp Bucher, Sanjeev Kumar

Studying the genetic basis of gene expression and chromatin organization is key to characterizing the effect of genetic variability on the function and structure of the human genome. Here we unravel how genetic variation perturbs gene regulation using a da ...

2019

Effects of physiological self-crowding of DNA on shape and biological properties of DNA molecules with various levels of supercoiling

Giovanni Dietler, Julien Dorier, Yannis Burnier, Fabrizio Benedetti, Andrzej Stasiak, Aleksandre Japaridze, Robert Sebastian Kwapich

DNA in bacterial chromosomes and bacterial plasmids is supercoiled. DNA supercoiling is essential for DNA replication and gene regulation. However, the density of supercoiling in vivo is circa twice smaller than in deproteinized DNA molecules isolated from ...

Oxford University Press2015

Population Variation and Genetic Control of Modular Chromatin Architecture in Humans

Bart Deplancke, David Hacker, Sebastian Martin Waszak, Sunil Kumar Raghav, Nouria Hernandez, Gilles Udin, Alisa Yurovsky, Sarah Thurnheer

Chromatin state variation at gene regulatory elements is abundant across individuals, yet we understand little about the genetic basis of this variability. Here, we profiled several histone modifications, the transcription factor (TF) PU.1, RNA polymerase ...

Elsevier2015

A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks

Bart Deplancke, Sebastian Martin Waszak, Sunil Kumar Raghav, Alina Isakova, Jovan Simicevic, Jean-Daniel Feuz, Antonina Iagovitina

The comprehensive mapping of gene promoters and enhancers has significantly improved our understanding of how the mammalian regulatory genome is organized. An important challenge is to elucidate how these regulatory elements contribute to gene expression b ...

Nature / European Molecular Biology Organization2013

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N-Acetoxy-acetylaminofluorene reacts preferentially with a control region of intracellular SV40 chromosome

Meeting our Makers:Uncovering the cis-regulatory activity of transposable elements using statistical learning

Statistical learning quantifies transposable element-mediated cis-regulation

Chromatin modules and their implication in genomic organization and gene regulation

Chromatin Proteomics to Study Epigenetics - Challenges and Opportunities

Toward a mechanistic understanding of variable chromatin modules

Induction of a chromatin boundary in vivo upon insertion of a tad border

Chromatin three-dimensional interactions mediate genetic effects on gene expression

Effects of physiological self-crowding of DNA on shape and biological properties of DNA molecules with various levels of supercoiling

Population Variation and Genetic Control of Modular Chromatin Architecture in Humans

A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks

Graph Chatbot

Chat with Graph Search

Meeting our Makers:Uncovering the cis-regulatory activity of transposable elements using statistical learning

Statistical learning quantifies transposable element-mediated cis-regulation

Population Variation and Genetic Control of Modular Chromatin Architecture in Humans

Toward a mechanistic understanding of variable chromatin modules

Induction of a chromatin boundary in vivo upon insertion of a tad border

Chromatin modules and their implication in genomic organization and gene regulation

Chromatin three-dimensional interactions mediate genetic effects on gene expression

Effects of physiological self-crowding of DNA on shape and biological properties of DNA molecules with various levels of supercoiling

Chromatin Proteomics to Study Epigenetics - Challenges and Opportunities

A yeast one-hybrid and microfluidics-based pipeline to map mammalian gene regulatory networks