Publication
In vivo targeted mutagenesis of a regulatory element required for positioning the Hoxd-11 and Hoxd-10 expression boundaries
Related publications (42)
Transposable elements and their KRAB/KAP1 controllers broadly regulate transcription in adult human cells
KAP1 is a universal corepressor for the large family of KRAB-ZFP proteins that coordinates epigenetic silencing of endogenous retroelements (EREs) during early embryonic development. This process is essential not just to prevent replication of EREs, but al ...
EPFL2015The Developmental Control of Transposable Elements and the Evolution of Higher Species
Didier Trono, Marc Samuel Friedli
Transposable elements (TEs) account for at least 50% of the human genome. They constitute essential motors of evolution through their ability to modify genomic architecture, mutate genes and regulate gene expression. Accordingly, TEs are subject to tight e ...
Annual Reviews2015Multiple Dual C–Cl Isotope Patterns Associated with Reductive Dechlorination of Tetrachloroethene
Christof Holliger, Julien Maillard, Géraldine Florence Buttet
Dual isotope slopes are increasingly used to identify transformation pathways of contaminants. We investigated if reductive dechlorination of tetrachloroethene (PCE) by consortia containing bacteria with different reductive dehalogenases (rdhA) genes can l ...
Amer Chemical Soc2014An ancestral regulatory mechanism underlies Hoxd gene expression in both developing genitals and digits
Coordinated expression of HoxD cluster genes is crucial for the emergence and patterning of both developing digits and external genitalia. As a shared evolutionary origin has been proposed for these secondary structures, which may have accompanied the tran ...
EPFL2013Polycomb Recruitment and Targeting in Mammals
Polycomb- (PcG) and trithorax (trxG) group proteins are essential components in the regulation of multiple developmental regulators. In particular, during early stages, they act as chromatin modifiers in such a way as to set and maintain the transcriptiona ...
EPFL2013The Hourglass and the Early Conservation Models-Co-Existing Patterns of Developmental Constraints in Vertebrates
Developmental constraints have been postulated to limit the space of feasible phenotypes and thus shape animal evolution. These constraints have been suggested to be the strongest during either early or mid-embryogenesis, which corresponds to the early con ...
Public Library Science2013Genomic context analysis reveals dense interaction network between vertebrate ultraconserved non-coding elements
Philipp Bucher, Slavica Dimitrieva Janeva
Motivation: Genomic context analysis, also known as phylogenetic profiling, is widely used to infer functional interactions between proteins but rarely applied to non-coding cis-regulatory DNA elements. We were wondering whether this approach could provide ...
Oxford University Press2012Chromosome Conformation Capture Uncovers Potential Genome-Wide Interactions between Human Conserved Non-Coding Sequences
Didier Trono, Isabelle Barde, Sonia Verp, Marc Samuel Friedli
Comparative analyses of various mammalian genomes have identified numerous conserved non-coding (CNC) DNA elements that display striking conservation among species, suggesting that they have maintained specific functions throughout evolution. CNC function ...
Public Library of Science2011The Interplay between Cytidine Deaminases, HIV and Domesticated Genetic Parasites
"There is more virus in us than us in us". John Coffin's famous sentence illustrates that particular nucleic acid sequences related to exogenous viruses, called retrotransposons, constitute almost half of the human genome and largely exceeds the amount of ...
EPFL2010VE-statin/egfl7 expression in endothelial cells is regulated by a distal enhancer and a proximal promoter under the direct control of Erg and GATA-2
Angiogenesis is the process by which new blood vessels arise from existing ones by the budding out of endothelial cell capillaries from the luminal side of blood vessels. Blood vessel formation is essential for organ development during embryogenesis and is ...
Public Library of Science2010