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Colinearity and functional hierarchy among genes of the homeotic complexes

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Genetic control of murine limb morphogenesis: relationships with human syndromes and evolutionary relevance

Denis Duboule, Jozsef Zakany

Over the past ten years, the discovery and functional characterisation of murine Hox genes has led to a better understanding of some of the molecular mechanisms underlying limb development. It has also shed some light on the potential genetic events which ...

1998

Hox gene induction in the neural tube depends on three parameters: competence, signal supply and paralogue group

Anne Grapin-Botton

It has been previously shown that Hox gene expression in the rhombencephalon is controlled by environmental cues. Thus posterior transposition of anterior rhombomeres to the r7/8 level results in the activation of Hox genes of the four first paralog groups ...

1997

A phylogenetically conserved transcriptional enhancer necessary for the activation of Hoxd-11 was deleted from the HoxD complex of mice by targeted mutagenesis. While genetic and expression analyses demonstrated the role of this regulatory element in the a ...

1997

[Genetic control of rhombencephalon development by Hox genes studied in bird embryo by the quail-chick chimera method]

Anne Grapin-Botton

The rhombencephalic neural tube is transiently segmented along the anteroposterior axis into 8 rhombomeres. Each rhombomere, as well as its derived neural crest cells, is characterized by the expression of a specific set of Hox genes which constitute its H ...

1997

Plasticity of transposed rhombomeres: Hox gene induction is correlated with phenotypic modifications

Anne Grapin-Botton

In this study we have analysed the expression of Hoxb-4, Hoxb-1, Hoxa-3, Hoxb-3, Hoxa-4 and Hoxd-4 in the neural tube of chick and quail embryos after rhombomere (r) heterotopic transplantations within the rhombencephalic area. Grafting experiments were ca ...

1995

Developmental expression of the mouse Evx-2 gene: relationship with the evolution of the HOM/Hox complex

Denis Duboule

The mouse Evx-2 gene is located in the immediate vicinity of the Hoxd-13 gene, the most posteriorly expressed gene of the HOXD complex. While the Evx-1 gene is also physically linked to the HOXA complex, it is more distantly located from the corresponding ...

1994

Conservation of a functional hierarchy between mammalian and insect Hox/HOM genes

Denis Duboule

We have generated several transgenic Drosophila strains containing different mouse Hox genes under heat shock control and studied how their generalized expression affects Drosophila larval patterns. We find that they have spatially restricted effects which ...

1994

Vertebrate Hox genes are essential for the proper organization of the body plan during development. Inactivation of these genes usually leads to important alterations, or transformations, in the identities of the affected developing structures. Hox genes a ...

1994

It is unknown whether cross-regulatory interactions between homeotic genes, which have been shown to play an important role in the maintenance of their expression domains during Drosophila development, are also important during mammalian development. We ha ...

1993

Reconstruction from serial sections: A tool for developmental biology. Application to Hox genes expression in chicken wing buds

Denis Duboule

A method for analysing the localization of the Hox-4 gene complex by three-dimensional reconstruction of serial cross-sections is presented. It allows the simultaneous visualization of three Hox expression domains on the same reconstructed embryo and the s ...

1993