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ORIGAMI - Folded Plate Structures, Engineering

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Undergraduate group projects: Challenges and learning experiences

Roland John Tormey, Siara Ruth Isaac

Working in groups and managing projects are important professional skills for engineers, and there is a growing demand to teach and assess such skills. But what should be taught and when? Tuckman’s famous “stages of development of performing groups” provid ...

2015

Peptide ligands stabilized by small molecules

Christian Heinis, Florence Pojer, Alessandro Angelini, Shiyu Chen, Davide Bertoldo

Bicyclic peptides generated through directed evolution by using phage display offer an attractive ligand format for the development of therapeutics. Being nearly 100-fold smaller than antibodies, they promise advantages such as access to chemical synthesis ...

Wiley-V C H Verlag Gmbh2014

Approximation Algorithms for the Interval Constrained Coloring Problem

We consider the interval constrained coloring problem, which appears in the interpretation of experimental data in biochemistry. Monitoring hydrogen-deuterium exchange rates via mass spectroscopy experiments is a method used to obtain information about pro ...

2011

Solute energy based REMD

Molecular dynamics (MD) simulations have increasingly contributed to the understanding of biomolecular processes, allowing for predictions of thermodynamic and structural properties. Unfortunately, the holy grail of protein structure prediction was soon fo ...

EPFL2008

Discrete breathers in protein structures

Francesco Piazza

Recently, using a numerical surface cooling approach, we have shown that highly energetic discrete breathers (DBs) can form in the stiffest parts of nonlinear network models of large protein structures. In the present study, using an analytical approach, w ...

2008

Amyloid ß-derived switch-peptides as tool to study conformational changes relevant in degenerative diseases

Marie-Stéphanie Camus

The rapid growing number of patients diagnosed with a neurodegenerative disease and more particularly with Alzheimer's disease (AD) has stimulated intensive research in determining and understanding biological phenomena causing such devastating diseases an ...

EPFL2008

The materials science of protein aggregation

Hilal Lashuel

Numerous human diseases are associated with conformational change and aggregation of proteins, including Alzheimer's, Parkinson's, prion diseases (such as mad cow disease), familial amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), Huntington's ...

Materials Research Society2005

The central domain of the matrix protein of HIV-1: influence on protein structure and virus infectivity

Oliver Hantschel

The central region of the matrix protein p17 of HIV-1 is known to be essential during virus assembly. We substituted alanines for amino acid triplets in this region of p17 (amino acid residues 47 to 55: NPG LLE TSE). Introduction of the respective mutation ...

Walter de Gruyter2004

POEtic Tissue: An Integrated Architecture for Bio-inspired Hardware

Dario Floreano, Eduardo Sanchez, Daniel Mange

It is clear to all, after a moments thought, that nature has much wemight be inspired by when designing our systems, for example: robustness, adaptability and complexity, to name a few. The implementation of bio-inspired systems in hardware has however bee ...

Springer2003

Transposing multimedia into a virtual course

Olivier Burdet

The present paper describes the challenges posed by transposing a successful conventional course into an – hopefully – equally successful web-based course, with the name i-Structures. This work is under way as part of the Swiss Virtual Campus project. The ...

4th International Conference on New Educational Environments2002