Publications related to Visceral obesity is associated with high levels of serum squalene

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Women with intrahepatic cholestasis of pregnancy (ICP), a disorder characterised by raised serum bile acids, are at increased risk of developing gestational diabetes mellitus and have impaired glucose tolerance whilst cholestatic. FXR and TGR5 are modulato ...

NATURE PUBLISHING GROUP2020

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Johan Auwerx, Dina Hofer

N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl-coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues r ...

FEDERATION AMER SOC EXP BIOL2019

Sorbitol Demineralization by Ion Exchange

Edgard Gnansounou, Binod Parameswaran

Sorbitol is a sugar alcohol commonly known as D-glucitol. It is synthesized from glucose by a reduction reaction altering the aldehyde group to a hydroxyl group. The body slowly metabolizes sorbitol, minimizing the possibility of increasing the insulin lev ...

Springer Nature2019

Three-Dimensional Model and Evaluation of an Insulin Injection Pen for Precise Dose Capacitive Measurement

Catherine Dehollain, Maria-Alexandra Paun, Jean-Baptiste Robert Orhan

A fully parameterized three-dimensional model with specific dimensions has been developed in ANSYS for an insulin injection pen used by diabetic persons. The insulin injection pen has a smart pen cap which hosts four electrodes used for the smart pen cap e ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2019

The NAD(+)-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

Vera Monica Lemos Da Silva

Insulin resistance is a major predictor of the development of metabolic disorders. Sirtuins (SIRTs) have emerged as potential targets that can be manipulated to counteract age-related diseases, including type 2 diabetes. SIRT2 has been recently shown to ex ...

Oxford Univ Press2017

Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage

Pierre Magistretti, Kim Do

Glutathione (GSH) deficits have been observed in several mental or degenerative illness, and so has the metabolic syndrome. The impact of a decreased glucose metabolism on the GSH system is well-known, but the effect of decreased GSH levels on the energy m ...

Frontiers Media Sa2016

SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting

Carlos Canto Alvarez, Patrick Descombes, Sylviane Métairon

Caloric restriction (CR) has been shown to prevent the onset of insulin resistance and to delay age-related physiological decline in mammalian organisms. SIRT1, a NAD(+) -dependent deacetylase enzyme, has been suggested to mediate the adaptive responses to ...

Elsevier2016

Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin

Carlos Canto Alvarez, Patrick Descombes, Sylviane Métairon, Richardus Houtkooper, Catherine Maclachlan, Joanna Ratajczak, Wen Gao

Mitochondrial function can be influenced by mitochondrial shape and connectivity with other cellular organelles through fusion and fission processes. Disturbances in mitochondrial architecture and mitochondrial fusion related genes are observed in situatio ...

American Diabetes Association2016

Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences

Carlos Canto Alvarez

Aging is the major risk factor for a constellation of multifactorial diseases, including insulin resistance, diabetes and cardiovascular complications. Dietary restriction has been shown to delay or prevent the manifestation of age-related health decline, ...

Cambridge Univ Press2016

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Visceral obesity is associated with high levels of serum squalene

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Sorbitol Demineralization by Ion Exchange

Three-Dimensional Model and Evaluation of an Insulin Injection Pen for Precise Dose Capacitive Measurement

The NAD(+)-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage

SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting

Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin

Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences

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Chat with Graph Search

Maternal glucose homeostasis is impaired in mouse models of gestational cholestasis

Glutamate Cysteine Ligase-Modulatory Subunit Knockout Mouse Shows Normal Insulin Sensitivity but Reduced Liver Glycogen Storage

Sorbitol Demineralization by Ion Exchange

The NAD(+)-dependent deacetylase SIRT2 attenuates oxidative stress and mitochondrial dysfunction and improves insulin sensitivity in hepatocytes

Three-Dimensional Model and Evaluation of an Insulin Injection Pen for Precise Dose Capacitive Measurement

Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

SIRT1 Gain of Function Does Not Mimic or Enhance the Adaptations to Intermittent Fasting

Mfn1 Deficiency in the Liver Protects Against Diet-Induced Insulin Resistance and Enhances the Hypoglycemic Effect of Metformin

Dietary restriction and Sirtuin 1 in metabolic health: connections and divergences