Improved ¹H-[¹³C] and ¹H NMR methods for in vivo measurement of cerebral metabolism
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We present the first single-chip array of integrated NMR receivers for parallel spectroscopy and imaging. The array, optimized for operation at 300 MHz, is composed of eight separate channels, with each channel consisting of a detection coil, a tuning capa ...
DFT methods in combination with NMR spectroscopy are used to investigate possible variants of the mol. structure of the ion pairs of the ionic liq. (IL) 1-ethyl-3-methylimidazolium tetrafluoroborate, [EMIM][BF4], in dichloromethane. According to the comput ...
The advantages offered by ultra-fast (>60 kHz) magic angle spinning (MAS) rotation for the Study of biological samples, notably containing paramagnetic centers are explored. It is shown that optimal conditions for performing solid-state C-13 NMR under 60 k ...
Multidimensional acquisitions play a central role in the progress and applications of nuclear magnetic resonance (NMR) spectroscopy. Such experiments have been collected traditionally as an array of one-dimensional scans, with suitably incremented delay pa ...
Multiple refocusing cycles can be used to extract transverse relaxation rates, R2, while homonuclear scalar couplings do not interfere. In this work, I have demonstrated the usefulness of a hybrid sequence, which is a compromise between single and multiple ...
Knowledge of proton T-2 relaxation time of metabolites is essential for proper quantitation of metabolite concentrations in localized proton spectroscopy, especially at moderate to long TEs. Although the T-2 relaxation time of singlets, such as that of cre ...
A transverse-dephasing optimized (SE)-E-3 (spin-state selective excitation) method is implemented in solid-state NMR experiments of uniformly labeled protein samples, and it is shown to provide a simultaneous significant gain in both resolution (up to a fa ...
The molecular dynamics of a series of organometallic complexes covalently bound to amorphous silica surfaces is determined experimentally using solid-state nuclear magnetic resonance (NMR) spectroscopy and density functional theory calculations (DFT). The ...
In this study, we present a methodology for metabotyping of C. elegans using (1)H high resolution magic angle spinning (HRMAS) whole-organism nuclear magnetic resonance (NMR). We demonstrate and characterize the robustness of our metabolic phenotyping meth ...