3D model of bone remodeling coupled with a drug effect
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The primary stability of cementless femoral components is crucial for the long-term success of total hip arthroplasty. The mechanisms which influence this stability are not yet well understood. However, mechanical environment in peri-implant tissue is know ...
After a fracture, fixing a plate to a broken bone can be problematic if the bone suffers of osteoporosis. In order to find a solution to increase bone density around the plate screws, one solution is to insert a drug-delivering bone plug that inhibits bone ...
Diffusion-controlled hydrogel polymeric matrix devices have been among the most widely used drug delivery systems. How ever in homogeneous hydrogel the diffusional distance increase with time and hence, the release rate decreases. That results in high rele ...
HEMA hydrogels are hydrophobic biocompatible hydrogel with high mechanical and viscoelastic properties, which are widely used in biomedical application including drug delivery systems. The mechanical properties and permeability of these hydrogels can be tu ...
Drug delivery is one of the most common clinical routines in hospitals, and is critical to patients’ health and recovery. It includes a decision making process in which a medical doctor decides the amount (dose) and frequency (dose interval) on the basis o ...
The present work forms part of an ongoing effort at the Laboratory of Polymer and Composite Technology (LTC) to develop novel solvent-free processing methods for next generation resorbable porous scaffolds for bone replacement, based on supercritical carbo ...
There is increasing evidence that mechanical stimulation affects the fate of tissue engineering scaffolds. In clinical situations, it is critical to accelerate bone formation inside the scaffold to reduce the recovery time and increase the chance of succes ...
Objective To miniaturize the loaded implant model to permit its application to small rodents. In this model, two titanium implants are placed 8 mm apart with their heads protruding from the skin and are forced together by a dedicated actuator. To assess th ...
The primary stability of cementless femoral components is crucial for the long-term success of total hip arthroplasty. We know that the healing phase after surgery is a complex biological process, which is affected by the mechanical environment. Implant lo ...
The goal of this study was to investigate if the preparation of implantation site has an impact on bone formation inside tissue engineering scaffolds. For this purpose, two different drilling techniques were used to create a hole in distal femurs of rats b ...
