Alpha-2 adrenergic receptorThe alpha-2 (α2) adrenergic receptor (or adrenoceptor) is a G protein-coupled receptor (GPCR) associated with the Gi heterotrimeric G-protein. It consists of three highly homologous subtypes, including α2A-, α2B-, and α2C-adrenergic. Some species other than humans express a fourth α2D-adrenergic receptor as well. Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α2-adrenergic receptor in the central and peripheral nervous systems.
Vertex figureIn geometry, a vertex figure, broadly speaking, is the figure exposed when a corner of a polyhedron or polytope is sliced off. Take some corner or vertex of a polyhedron. Mark a point somewhere along each connected edge. Draw lines across the connected faces, joining adjacent points around the face. When done, these lines form a complete circuit, i.e. a polygon, around the vertex. This polygon is the vertex figure. More precise formal definitions can vary quite widely, according to circumstance.
Uniform polyhedronIn geometry, a uniform polyhedron has regular polygons as faces and is vertex-transitive (i.e., there is an isometry mapping any vertex onto any other). It follows that all vertices are congruent. Uniform polyhedra may be regular (if also face- and edge-transitive), quasi-regular (if also edge-transitive but not face-transitive), or semi-regular (if neither edge- nor face-transitive). The faces and vertices need not be convex, so many of the uniform polyhedra are also star polyhedra.
Icosahedral honeycombIn geometry, the icosahedral honeycomb is one of four compact, regular, space-filling tessellations (or honeycombs) in hyperbolic 3-space. With Schläfli symbol {3,5,3}, there are three icosahedra around each edge, and 12 icosahedra around each vertex, in a regular dodecahedral vertex figure. The dihedral angle of a regular icosahedron is around 138.2°, so it is impossible to fit three icosahedra around an edge in Euclidean 3-space. However, in hyperbolic space, properly scaled icosahedra can have dihedral angles of exactly 120 degrees, so three of those can fit around an edge.
DodecahedronIn geometry, a dodecahedron (; ) or duodecahedron is any polyhedron with twelve flat faces. The most familiar dodecahedron is the regular dodecahedron with regular pentagons as faces, which is a Platonic solid. There are also three regular star dodecahedra, which are constructed as stellations of the convex form. All of these have icosahedral symmetry, order 120.
PharmacologyPharmacology is a branch of medicine, biology, and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemical or physiological effect on the cell, tissue, organ, or organism (sometimes the word pharmacon is used as a term to encompass these endogenous and exogenous bioactive species). It is the science of drugs including their origin, composition, pharmacokinetics, therapeutic use, and toxicology.
HexagonIn geometry, a hexagon (from Greek ἕξ, hex, meaning "six", and γωνία, gonía, meaning "corner, angle") is a six-sided polygon. The total of the internal angles of any simple (non-self-intersecting) hexagon is 720°. A regular hexagon has Schläfli symbol {6} and can also be constructed as a truncated equilateral triangle, t{3}, which alternates two types of edges. A regular hexagon is defined as a hexagon that is both equilateral and equiangular. It is bicentric, meaning that it is both cyclic (has a circumscribed circle) and tangential (has an inscribed circle).
Uniform 4-polytopeIn geometry, a uniform 4-polytope (or uniform polychoron) is a 4-dimensional polytope which is vertex-transitive and whose cells are uniform polyhedra, and faces are regular polygons. There are 47 non-prismatic convex uniform 4-polytopes. There are two infinite sets of convex prismatic forms, along with 17 cases arising as prisms of the convex uniform polyhedra. There are also an unknown number of non-convex star forms.
Mechanism of actionIn pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. A mechanism of action usually includes mention of the specific molecular targets to which the drug binds, such as an enzyme or receptor. Receptor sites have specific affinities for drugs based on the chemical structure of the drug, as well as the specific action that occurs there.
Therapeutic indexThe therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug. It is a comparison of the amount of a therapeutic agent that causes the therapeutic effect to the amount that causes toxicity. The related terms therapeutic window or safety window refer to a range of doses optimized between efficacy and toxicity, achieving the greatest therapeutic benefit without resulting in unacceptable side-effects or toxicity.
