Publications related to Induction of tau pathology by intracerebral infusion of amyloid-beta-containing brain extract and by amyloid-beta deposition in APP x tau transgenic mice

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

Today, more than 40 million people worldwide are affected by neurodegenerative disorders. Onset of these diseases is associated with insoluble fibrillar protein aggregates, termed amyloids. The molecular origin and the link between amyloid formation and di ...

EPFL2015

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

Patrick Aebischer, Bernard Schneider, Jean-Charles Bensadoun

Adeno-associated virus serotype 6 (AAV6) viral vectors encoding mutant and normal tau were used to produce focal tau pathology. Two mutant forms of tau were used; the P301S tau mutation is associated with neurofibrillary tangle formation in humans, and the ...

Elsevier Science Inc2013

Transgenic expression of beta 1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice

Maurizio Molinari, Paolo Paganetti

Heterologous expression of the functional amyloid beta (A beta) antibody beta 1 in the central nervous system was engineered to maximize antibody exposure in the brain and assess the effects on A beta production and accumulation in these conditions. A sing ...

Elsevier Science Inc2013

Imaging brain amyloid deposition using grating-based differential phase contrast tomography

Patrick Aebischer, Jean-Charles Bensadoun, Peter Modregger, Marco Stampanoni

One of the core pathological features of Alzheimer's disease (AD) is the accumulation of amyloid plaques in the brain. Current efforts of medical imaging research aim at visualizing amyloid plaques in living patients in order to evaluate the progression of ...

Elsevier2012

Development of a Small D-Enantiomeric Alzheimer's Amyloid-beta Binding Peptide Ligand for Future In Vivo Imaging Applications

Andrea Pfeifer, Andreas Muhs

Alzheimer's disease (AD) is a devastating disease affecting predominantly the aging population. One of the characteristic pathological hallmarks of AD are neuritic plaques, consisting of amyloid-beta peptide (A beta). While there has been some advancement ...

Public Library Science2012

The Gamma-Secretase-Mediated Proteolytic Processing of APP C-Terminal Fragments as a Therapeutic Target for Alzheimer's Disease

Jemila Houacine

Alzheimer's disease (AD) is a devastating neurodegenerative disorder which severely impairs cognitive functions by triggering neuronal cell death and synaptic loss, and finally leads the patients to death. Two main histopathological hallmarks can be found ...

EPFL2011

Gamma-Secretase Dependent Gene Expression

Alexandra Marie-Isabelle Karoline Brigitte Magold

The causes of sporadic Alzheimer's Disease (AD), the most common form of dementia at old age, are still unknown. Familial early onset AD (FAD) is mainly caused by mutations of Presenilins (PS), the active subunits of γ-secretase. Processing of its substrat ...

EPFL2011

Investigation of the role of PICALM on amyloid metabolism in a transgenic mouse model of Alzheimer’s disease

Dominique Rubi

Recently, two large independent genome-wide association studies have provided compelling evidence that polymorphisms at the phosphatidylinositol-binding clathrin assembly protein (PICALM) locus are linked to Alzheimer’s disease (AD). At the cellular level, ...

2011

Co-pathological states of tau proteins in a 3D micropatterned neural cell culture

Philippe Renaud, Robert Meissner, Anja Kunze, Serena Brando

In vitro studies of Alzheimer’s disease are based on homogenously seeded neural cells. These studies reveal molecular pathway mechanism related to neurite degeneration, but they cannot analyze interactions between diseased and healthy cells. Furthermore, t ...

2011

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

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) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

Induction of tau pathology by intracerebral infusion of amyloid-beta-containing brain extract and by amyloid-beta deposition in APP x tau transgenic mice

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New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

Transgenic expression of beta 1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice

Imaging brain amyloid deposition using grating-based differential phase contrast tomography

Development of a Small D-Enantiomeric Alzheimer's Amyloid-beta Binding Peptide Ligand for Future In Vivo Imaging Applications

The Gamma-Secretase-Mediated Proteolytic Processing of APP C-Terminal Fragments as a Therapeutic Target for Alzheimer's Disease

Gamma-Secretase Dependent Gene Expression

Investigation of the role of PICALM on amyloid metabolism in a transgenic mouse model of Alzheimer’s disease

Co-pathological states of tau proteins in a 3D micropatterned neural cell culture

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

The Gamma-Secretase-Mediated Proteolytic Processing of APP C-Terminal Fragments as a Therapeutic Target for Alzheimer's Disease

Imaging brain amyloid deposition using grating-based differential phase contrast tomography

Co-pathological states of tau proteins in a 3D micropatterned neural cell culture

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Investigation of the role of PICALM on amyloid metabolism in a transgenic mouse model of Alzheimer’s disease

Focal expression of adeno-associated viral-mutant tau induces widespread impairment in an APP mouse model

New Insights Into Amyloid Formation and Structure by Innovative Atomic Force Microscopy Methods

Development of a Small D-Enantiomeric Alzheimer's Amyloid-beta Binding Peptide Ligand for Future In Vivo Imaging Applications

Transgenic expression of beta 1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice

Gamma-Secretase Dependent Gene Expression