Publication

Static compression is associated with decreased diffusivity of dextrans in cartilage explants

Related publications (33)

Enhancing Chondrocyte Biosynthetic Activities: Harnessing the Power of Loading-Induced Evolved Temperature

Chondrocytes within articular cartilage possess the capacity to perceive and react to signals generated by the typical load-bearing actions of daily life, such as walking or running. Articular cartilage is predominantly oriented toward compression-based fu ...

EPFL2024

Synergetic Support of Cartilage Homeostasis via Coupled Thermal-Hydrostatic Pressure Stimuli

Yanheng Guo

Cartilage homeostasis, crucial for musculoskeletal function, is orchestrated by interconnected biophysical cues. In healthy cartilage, repetitive compressive loading not only elicits a range of mechanical stimuli but also induces a gradual transient temper ...

EPFL2024

Mimicking Loading-Induced Cartilage Self-Heating in Vitro Promotes Matrix Formation in Chondrocyte-Laden Constructs with Different Mechanical Properties

Dominique Pioletti, Peyman Karami, Naser Nasrollahzadeh Mamaghani, Theofanis Stampoultzis, Yanheng Guo

Articular cartilage presents a mechanically sensitive tissue. Chondrocytes, the sole cell type residing in the tissue, perceive and react to physical cues as signals that significantly modulate their behavior. Hyaline cartilage is a connective tissue with ...

2023

Thoughts on cartilage tissue engineering: A 21st century perspective

Dominique Pioletti, Peyman Karami, Theofanis Stampoultzis

In mature individuals, hyaline cartilage demonstrates a poor intrinsic capacity for repair, thus even minor defects could result in progressive degeneration, impeding quality of life. Although numerous attempts have been made over the past years for the ad ...

2021

Extracellular Matrix Production by Mesenchymal Stromal Cells in Hydrogels Facilitates Cell Spreading and Is Inhibited by FGF-2

Martin Ehrbar, Queralt Vallmajó Martín

In native tissues, the interaction between cells and the surrounding extracellular matrix (ECM) is reciprocal, as cells not only receive signals from the ECM but also actively remodel it through secretion of cell-derived ECM. However, very little is known ...

2020

Tailoring the Mechanical Properties of Tissue Engineering Scaffolds made from Decellularized Cartilage

Jens Antons

Due to its limited regeneration capacity, articular cartilage defects are considered a frequent clinical problem. Initial cartilage defects, if left untreated, will progress in severity over time and can eventually lead to degenerative joint diseases such ...

EPFL2019

Depth-dependent mechanical properties of human articular cartilage obtained by indentation measurements

Pierre-Etienne Bourban, Lee Ann Laurent-Applegate, Robin Martin, Matteo Gregorio Modesto Marascio, Jens Antons

Emerging 3D printing technology permits innovative approaches to manufacture cartilage scaffolds associated with layer-by-layer mechanical property adaptation. However, information about gradients of mechanical properties in human articular cartilage is li ...

2018

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy

Melody Swartz, Witold Waldemar Kilarski, Amanda Waite Lund, Manuel Andreas Fankhauser

Besides being a physical scaffold to maintain tissue morphology, the extracellular matrix (ECM) is actively involved in regulating cell and tissue function during development and organ homeostasis. It does so by acting via biochemical, biomechanical, and b ...

Journal Of Visualized Experiments2014

Intrinsic viscoelasticity increases temperature in knee cartilage under physiological loading

Dominique Pioletti, Philippe Abdel Sayed, Mohamadreza Nassajian Moghadam

Metabolism of proteoglycans and hyaluronic acid has been shown to be temperature- dependent in cartilage explants, with optimal anabolic effects between 36 1C and 38 1C. At rest, the temperature of human knee has a value of around 33 1C. We aim to show in ...

Elsevier2014

Dissipation as variable in cartilage mechanobiology

Philippe Abdel Sayed

Mechanobiology is the analysis of the role of mechanical forces in educing a molecular response in cells. Nowadays, mechanobiology may contribute to clinical progress. In particular, mechanical stimulation has been proposed to induce chondrogenesis in engi ...

EPFL2013

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.