Publication

Intraluminal pressure modulates the magnitude and the frequency of induced vasomotion in rat arteries

Abstract

Arterial vasomotion and its relation to intraluminal pressure were investigated in vitro in isolated rat arteries. Femoral arteries (mean diameter = 768.2 +/- 25 microns, n = 5) and mesenteric arteries (mean diameter = 393.4 +/- 32 microns, n = 5) were used in this study. Arterial segments were excised, mounted on microcannulas and perfused with Tyrode's solution at a constant flow (100 microliters/min). After equilibration, intraluminal pressure was stepwise changed from 0 to 120 mm Hg. The changes in the outer diameter of the vessels were measured continuously over a period of 4 h after the equilibration. Vasomotion was induced by constrictor agonists (norepinephrine 10(-6) M for mesenteric arteries and norepinephrine 10(-6) M + Bay K8644 10(-7) M for femoral arteries) and was maintained only in the presence of the above-mentioned drugs. Both vasomotion magnitude and frequency are modulated by pressure. Vasomotion frequency increases with pressure increase. When intraluminal pressure varied between 0 and 120 mm Hg, vasomotion frequency varied between 0.19 and 0.49 Hz for mesenteric arteries and between 0.04 and 0.23 Hz for femoral arteries. Thus, vasomotion frequency differed clearly between the two vessel types. Vasomotion amplitude shows a biphasic relationship with a maximum occurring at about 40 mm Hg for mesenteric arteries and 50 mm Hg for femoral arteries. Based on these findings, it is hypothesized that vasomotion amplitude relates to the active mechanical properties of the artery and, in particular, to its contractile capacity.

About this result
This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.
Related concepts (35)
Blood pressure
Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term "blood pressure" refers to the pressure in a brachial artery, where it is most commonly measured. Blood pressure is usually expressed in terms of the systolic pressure (maximum pressure during one heartbeat) over diastolic pressure (minimum pressure between two heartbeats) in the cardiac cycle.
Binary relation
In mathematics, a binary relation associates elements of one set, called the domain, with elements of another set, called the codomain. A binary relation over sets X and Y is a new set of ordered pairs (x, y) consisting of elements x in X and y in Y. It is a generalization of the more widely understood idea of a unary function. It encodes the common concept of relation: an element x is related to an element y, if and only if the pair (x, y) belongs to the set of ordered pairs that defines the binary relation.
Pressure
Pressure (symbol: p or P) is the force applied perpendicular to the surface of an object per unit area over which that force is distributed. Gauge pressure (also spelled gage pressure) is the pressure relative to the ambient pressure. Various units are used to express pressure. Some of these derive from a unit of force divided by a unit of area; the SI unit of pressure, the pascal (Pa), for example, is one newton per square metre (N/m2); similarly, the pound-force per square inch (psi, symbol lbf/in2) is the traditional unit of pressure in the imperial and US customary systems.
Show more
Related publications (37)

Shafranov shift correction to the Furth-Yoshikawa scaling of tokamak adiabatic compression

Olivier Sauter

In 1970, Furth and Yoshikawa (1970 Phys. Fluids 13 2593-6) introduced the scalings of adiabatic plasma compression. Basically, if the shape of the external plasma boundary and the aspect ratio are preserved during the compression, then the density, kinetic ...
IOP Publishing Ltd2023

Virtual reality to assess visual attraction and perceived interest to daylit scene variations

Marilyne Andersen, Caroline Karmann, Bahar Aydemir, Kynthia Chamilothori

Façades and light pattern composition have been shown to influence the spatial experience and physiological responses of humans [1,2]. The present study examines the effect of sunlight penetration and window size on fixations to the floor of the scene, and ...
2021

Model order reduction of flow based on a modular geometrical approximation of blood vessels

Simone Deparis, Luca Pegolotti

We are interested in a reduced order method for the efficient simulation of blood flow in arteries. The blood dynamics is modeled by means of the incompressible Navier–Stokes equations. Our algorithm is based on an approximated domain-decomposition of the ...
2021
Show more