Publications related to Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

A Therapy Parameter-based Model for Predicting Blood Glucose Concentrations in Patients with Type 1 Diabetes

Denis Gillet, Grégory François, Alain Bock

In this paper, the problem of predicting blood glucose concentrations (BG) for the treatment of patients with type 1 diabetes, is addressed. Predicting BG is of very high importance as most treatments, which consist in exogenous insulin injections, rely on ...

Elsevier2015

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy

Theo Lasser, Michael Friedrich, Rainer Leitgeb, Anne Grapin-Botton, Martin Villiger, Joan Goulley

Aims/hypothesis Structural and functional imaging of the islets of Langerhans and the insulin-secreting beta cells represents a significant challenge and a long-lasting objective in diabetes research. In vivo microscopy offers a valuable insight into beta ...

Springer Verlag2009

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

Rolf Gruetter, João Miguel das Neves Duarte

Type 1 diabetes can affect hippocampal function triggering cognitive impairment through unknown mechanisms. Caffeine consumption prevents hippocampal degeneration and memory dysfunction upon different insults and is also known to affect peripheral glucose ...

Wiley-Blackwell2009

The prolyl-aminodipeptidases and their inhibitors as therapeutic targets for fibrogenic disorders

Sandrine Gerber

Many biologically active peptides are protected from general proteolytic degradation by evolutionary conserved prolines (Pro), due to conformational constraints imposed by the Pro residue. Thus the biological importance of prolyl-specific peptidases points ...

2009

Targeting bile-acid signalling for metabolic diseases

Johan Auwerx, Kristina Schoonjans

Bile acids are increasingly being appreciated as complex metabolic integrators and signalling factors and not just as lipid solubilizers and simple regulators of bile-acid homeostasis. It is therefore not surprising that a number of bile-acid-activated sig ...

2008

Aggravation of viral hepatitis by platelet-derived serotonin

Nicola Harris

More than 500 million people worldwide are persistently infected with hepatitis B virus or hepatitis C virus. Although both viruses are poorly cytopathic, persistence of either virus carries a risk of chronic liver inflammation, potentially resulting in li ...

2008

Magnetic resonance elastography for the noninvasive staging of liver fibrosis

Najat Salameh

The purpose of our study was to prospectively compare the success rate and diagnostic accuracy of magnetic resonance elastography, ultrasound elastography, and aspartate aminotransferase to platelets ratio index (APRI) measurements for the noninvasive stag ...

2008

Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach

Didier Trono

AIMS/HYPOTHESIS: We examined a clinical model of ex vivo transdifferentiation of primary adult hepatocytes to insulin-secreting cells for the treatment of type 1 diabetes. MATERIALS AND METHODS: Isolated rat hepatocytes were transduced in primary culture w ...

Springer Verlag2006

Liver fibrosis: non-invasive assessment with MR elastography

Najat Salameh

The aim of this study was to assess the feasibility of using non-invasive MR elastography for determining the stage of liver fibrosis. Twenty-five consecutive patients who had liver biopsy for suspicion of chronic liver disease were included in the study. ...

Wiley-Blackwell2006

Targeting the TGR5-GLP-1 pathway to combat type 2 diabetes and non-alcoholic fatty liver disease

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A Therapy Parameter-based Model for Predicting Blood Glucose Concentrations in Patients with Type 1 Diabetes

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

The prolyl-aminodipeptidases and their inhibitors as therapeutic targets for fibrogenic disorders

Targeting bile-acid signalling for metabolic diseases

Aggravation of viral hepatitis by platelet-derived serotonin

Magnetic resonance elastography for the noninvasive staging of liver fibrosis

Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach

Liver fibrosis: non-invasive assessment with MR elastography

A Therapy Parameter-based Model for Predicting Blood Glucose Concentrations in Patients with Type 1 Diabetes

Adult rat liver cells transdifferentiated with lentiviral IPF1 vectors reverse diabetes in mice: an ex vivo gene therapy approach

Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats

The prolyl-aminodipeptidases and their inhibitors as therapeutic targets for fibrogenic disorders

Aggravation of viral hepatitis by platelet-derived serotonin

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

Liver fibrosis: non-invasive assessment with MR elastography

In vivo imaging of murine endocrine islets of Langerhans with extended-focus optical coherence microscopy

Magnetic resonance elastography for the noninvasive staging of liver fibrosis

Targeting bile-acid signalling for metabolic diseases