In vivo veritas: the search for TB drug targets goes live
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The discovery of new metal-based antitumor drugs, whether cisplatin derivs. or those based on other metals, has been largely based on cell viability assays (IC50 values) and compds. that bind to DNA. This approach has been applied for more than 30 years du ...
The antiparasitic effect of a collection of compounds with antimitotic activity has been tested on a mammalian cell line infected with Encephalitozoon intestinalis, a microsporidian causing intestinal and systemic infection in immunocompromised patients. T ...
(-)-(3aS,5S,6S,6aR)-3a,5,6,6a-Tetrahydro-5, 6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol ((-)-5) has been tested toward 25 glycohydrolases and found to inhibit beta-galactosidase from Aspergillus niger (K-i = 18 mu M) and that from Aspergillus oriz ...
We describe a model and implementation of evolutionary spiking neurons for embedded microcontrollers with few bytes of memory and very low power consumption. The approach is tested with an autonomous microrobot of less than 1 in^3 that evolves the ability ...
The evaluation of sepn. processes is demonstrated at the example of the title compd. (I) formed by biotransformation of 3-ethylpyridine with P. oleovorans. For extn., Aliquat 336 and Alamine 336 were tested. Extn. and back-extn. were employed simultaneousl ...
Idea shared between 1993 and 1996 between researchers from EPFL and other universities in Argentina, Bolivia, Brasil and Venezuela, with the support of the Foundation Leopold Mayer for the Progress of Man, alternative ways of urban planning have been teste ...
IREC-EPFL, FPH, Universidad Central de Venezuela1996
Liq. film mass transfer coeffs. in packed beds and strings of spheres were calcd. theor. using a penetration model for the mass transfer combined with the hydrodynamics of a laminar spherical falling film. The predictions were tested with packed beds varyi ...
We tested the theoretical prediction that the band structures on the opposite sides of a homojunction can be artificially displaced in energy with respect to each other by means of double intralayers of atomiclike thickness, producing band discontinuities ...
To achieve the quantum leap in understanding required to overcome two major human diseases, leprosy and tuberculosis, systematic and comparative genome analysis has been undertaken. New insight into the biology of their causative agents has been obtained a ...
Insects respond to microbial infection by the rapid and transient expression of several genes encoding potent antimicrobial peptides. Herein we demonstrate that this antimicrobial response of Drosophila is not aspecific but can discriminate between various ...