Publication

In vivo veritas: the search for TB drug targets goes live

Publications associées (62)

Metal-based antitumour drugs in the post genomic era

The discovery of new metal-based antitumor drugs, whether cisplatin derivs. or those based on other metals, has been largely based on cell viability assays (IC50 values) and compds. that bind to DNA. This approach has been applied for more than 30 years du ...

2006

Evolutionary Bits'n'Spikes

Dario Floreano, Gilles Caprari, Jesper Blynel

We describe a model and implementation of evolutionary spiking neurons for embedded microcontrollers with few bytes of memory and very low power consumption. The approach is tested with an autonomous microrobot of less than 1 in^3 that evolves the ability ...

MIT Press2002

In vitro activities of two antimitotic compounds, pancratistatin and 7-deoxynarciclasine, against Encephalitozoon intestinalis, a microsporidium causing infections in humans

The antiparasitic effect of a collection of compounds with antimitotic activity has been tested on a mammalian cell line infected with Encephalitozoon intestinalis, a microsporidian causing intestinal and systemic infection in immunocompromised patients. T ...

American Society for Microbiology2001

Comparative genomics of the leprosy and tubercle bacilli

Stewart Cole

To achieve the quantum leap in understanding required to overcome two major human diseases, leprosy and tuberculosis, systematic and comparative genome analysis has been undertaken. New insight into the biology of their causative agents has been obtained a ...

2000

Specific, uncompetitive inhibition of beta-galactosidases by a 5,6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol derivative

Pierre Vogel, Raynald Demange

(-)-(3aS,5S,6S,6aR)-3a,5,6,6a-Tetrahydro-5, 6-isopropylidenedioxyfuro[2,3-d]isoxazole-3-methanol ((-)-5) has been tested toward 25 glycohydrolases and found to inhibit beta-galactosidase from Aspergillus niger (K-i = 18 mu M) and that from Aspergillus oriz ...

1999

Drosophila host defense: differential induction of antimicrobial peptide genes after infection by various classes of microorganisms

Bruno Lemaitre

Insects respond to microbial infection by the rapid and transient expression of several genes encoding potent antimicrobial peptides. Herein we demonstrate that this antimicrobial response of Drosophila is not aspecific but can discriminate between various ...

National Academy of Sciences1998

Choice of a method for in situ recovery of 3-pyridylacetic acid formed by biotransformation with Pseudomonas oleovorans

Urs von Stockar, Ian William Marison

The evaluation of sepn. processes is demonstrated at the example of the title compd. (I) formed by biotransformation of 3-ethylpyridine with P. oleovorans. For extn., Aliquat 336 and Alamine 336 were tested. Extn. and back-extn. were employed simultaneousl ...

1996

A simplified penetration model for mass transfer in packed beds and strings of spheres

Urs von Stockar

Liq. film mass transfer coeffs. in packed beds and strings of spheres were calcd. theor. using a penetration model for the mass transfer combined with the hydrodynamics of a laminar spherical falling film. The predictions were tested with packed beds varyi ...

1996

New oportunities: Participating and Planning

Yves Pedrazzini, Jean-Claude Bolay, Antonio Da Cunha

Idea shared between 1993 and 1996 between researchers from EPFL and other universities in Argentina, Bolivia, Brasil and Venezuela, with the support of the Foundation Leopold Mayer for the Progress of Man, alternative ways of urban planning have been teste ...

IREC-EPFL, FPH, Universidad Central de Venezuela1996

Microscopic Manipulation of Homojunction Band Lineups

Giorgio Margaritondo

We tested the theoretical prediction that the band structures on the opposite sides of a homojunction can be artificially displaced in energy with respect to each other by means of double intralayers of atomiclike thickness, producing band discontinuities ...

1992

Graph Chatbot

Chattez avec Graph Search

Posez n’importe quelle question sur les cours, conférences, exercices, recherches, actualités, etc. de l’EPFL ou essayez les exemples de questions ci-dessous.

AVERTISSEMENT : Le chatbot Graph n'est pas programmé pour fournir des réponses explicites ou catégoriques à vos questions. Il transforme plutôt vos questions en demandes API qui sont distribuées aux différents services informatiques officiellement administrés par l'EPFL. Son but est uniquement de collecter et de recommander des références pertinentes à des contenus que vous pouvez explorer pour vous aider à répondre à vos questions.

Connectez-vous pour utiliser Chat avec Graph Search