Relative homologyIn algebraic topology, a branch of mathematics, the (singular) homology of a topological space relative to a subspace is a construction in singular homology, for pairs of spaces. The relative homology is useful and important in several ways. Intuitively, it helps determine what part of an absolute homology group comes from which subspace. Given a subspace , one may form the short exact sequence where denotes the singular chains on the space X. The boundary map on descends to and therefore induces a boundary map on the quotient.
Sequence analysisIn bioinformatics, sequence analysis is the process of subjecting a DNA, RNA or peptide sequence to any of a wide range of analytical methods to understand its features, function, structure, or evolution. Methodologies used include sequence alignment, searches against biological databases, and others. Since the development of methods of high-throughput production of gene and protein sequences, the rate of addition of new sequences to the databases increased very rapidly.
Singular homologyIn algebraic topology, singular homology refers to the study of a certain set of algebraic invariants of a topological space X, the so-called homology groups Intuitively, singular homology counts, for each dimension n, the n-dimensional holes of a space. Singular homology is a particular example of a homology theory, which has now grown to be a rather broad collection of theories. Of the various theories, it is perhaps one of the simpler ones to understand, being built on fairly concrete constructions (see also the related theory simplicial homology).
Protein–protein interactionProtein–protein interactions (PPIs) are physical contacts of high specificity established between two or more protein molecules as a result of biochemical events steered by interactions that include electrostatic forces, hydrogen bonding and the hydrophobic effect. Many are physical contacts with molecular associations between chains that occur in a cell or in a living organism in a specific biomolecular context. Proteins rarely act alone as their functions tend to be regulated.
Frameshift mutationA frameshift mutation (also called a framing error or a reading frame shift) is a genetic mutation caused by indels (insertions or deletions) of a number of nucleotides in a DNA sequence that is not divisible by three. Due to the triplet nature of gene expression by codons, the insertion or deletion can change the reading frame (the grouping of the codons), resulting in a completely different translation from the original. The earlier in the sequence the deletion or insertion occurs, the more altered the protein.
Consensus sequenceIn molecular biology and bioinformatics, the consensus sequence (or canonical sequence) is the calculated sequence of most frequent residues, either nucleotide or amino acid, found at each position in a sequence alignment. It represents the results of multiple sequence alignments in which related sequences are compared to each other and similar sequence motifs are calculated. Such information is important when considering sequence-dependent enzymes such as RNA polymerase.
Gene expressionGene expression is the process by which information from a gene is used in the synthesis of a functional gene product that enables it to produce end products, proteins or non-coding RNA, and ultimately affect a phenotype. These products are often proteins, but in non-protein-coding genes such as transfer RNA (tRNA) and small nuclear RNA (snRNA), the product is a functional non-coding RNA.
Homology (mathematics)In mathematics, homology is a general way of associating a sequence of algebraic objects, such as abelian groups or modules, with other mathematical objects such as topological spaces. Homology groups were originally defined in algebraic topology. Similar constructions are available in a wide variety of other contexts, such as abstract algebra, groups, Lie algebras, Galois theory, and algebraic geometry. The original motivation for defining homology groups was the observation that two shapes can be distinguished by examining their holes.
Protein designProtein design is the rational design of new protein molecules to design novel activity, behavior, or purpose, and to advance basic understanding of protein function. Proteins can be designed from scratch (de novo design) or by making calculated variants of a known protein structure and its sequence (termed protein redesign). Rational protein design approaches make protein-sequence predictions that will fold to specific structures.
Regulator geneA regulator gene, regulator, or regulatory gene is a gene involved in controlling the expression of one or more other genes. Regulatory sequences, which encode regulatory genes, are often at the five prime end (5') to the start site of transcription of the gene they regulate. In addition, these sequences can also be found at the three prime end (3') to the transcription start site. In both cases, whether the regulatory sequence occurs before (5') or after (3') the gene it regulates, the sequence is often many kilobases away from the transcription start site.
