Protein structureProtein structure is the three-dimensional arrangement of atoms in an amino acid-chain molecule. Proteins are polymers - specifically polypeptides - formed from sequences of amino acids, which are the monomers of the polymer. A single amino acid monomer may also be called a residue, which indicates a repeating unit of a polymer. Proteins form by amino acids undergoing condensation reactions, in which the amino acids lose one water molecule per reaction in order to attach to one another with a peptide bond.
Molecular machineMolecular machines are a class of molecules typically described as an assembly of a discrete number of molecular components intended to produce mechanical movements in response to specific stimuli, mimicking macromolecular devices such as switches and motors. Naturally occurring or biological molecular machines are responsible for vital living processes such as DNA replication and ATP synthesis. Kinesins and ribosomes are examples of molecular machines, and they often take the form of multi-protein complexes.
Gene-centered view of evolutionThe gene-centered view of evolution, gene's eye view, gene selection theory, or selfish gene theory holds that adaptive evolution occurs through the differential survival of competing genes, increasing the allele frequency of those alleles whose phenotypic trait effects successfully promote their own propagation. The proponents of this viewpoint argue that, since heritable information is passed from generation to generation almost exclusively by DNA, natural selection and evolution are best considered from the perspective of genes.
T1 spaceDISPLAYTITLE:T1 space In topology and related branches of mathematics, a T1 space is a topological space in which, for every pair of distinct points, each has a neighborhood not containing the other point. An R0 space is one in which this holds for every pair of topologically distinguishable points. The properties T1 and R0 are examples of separation axioms. Let X be a topological space and let x and y be points in X. We say that x and y are if each lies in a neighbourhood that does not contain the other point.
Kolmogorov spaceIn topology and related branches of mathematics, a topological space X is a T0 space or Kolmogorov space (named after Andrey Kolmogorov) if for every pair of distinct points of X, at least one of them has a neighborhood not containing the other. In a T0 space, all points are topologically distinguishable. This condition, called the T0 condition, is the weakest of the separation axioms. Nearly all topological spaces normally studied in mathematics are T0 spaces. In particular, all T1 spaces, i.e.
Specialization (pre)orderIn the branch of mathematics known as topology, the specialization (or canonical) preorder is a natural preorder on the set of the points of a topological space. For most spaces that are considered in practice, namely for all those that satisfy the T0 separation axiom, this preorder is even a partial order (called the specialization order). On the other hand, for T1 spaces the order becomes trivial and is of little interest. The specialization order is often considered in applications in computer science, where T0 spaces occur in denotational semantics.
CullinCullins are a family of hydrophobic scaffold proteins which provide support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs) that are highly diverse and play a role in myriad cellular processes, most notably protein degradation by ubiquitination. The human genome contains eight cullin genes CUL1, part of SCF complex CUL2, part of ECS complex (Elongin C - CUL2 - SOCS-box) CUL3, part of CUL3-BTB complex CUL4A CUL4B CUL5 CUL7 CUL9, also known as PARC There is also a more distant member called ANAPC2 (or APC2), part of the Anaphase-promoting complex.
