Genetically modified mouseA genetically modified mouse or genetically engineered mouse model (GEMM) is a mouse (Mus musculus) that has had its genome altered through the use of genetic engineering techniques. Genetically modified mice are commonly used for research or as animal models of human diseases, and are also used for research on genes. Together with patient-derived xenografts (PDXs), GEMMs are the most common in vivo models in cancer research. Both approaches are considered complementary and may be used to recapitulate different aspects of disease.
Self-oscillationSelf-oscillation is the generation and maintenance of a periodic motion by a source of power that lacks any corresponding periodicity. The oscillator itself controls the phase with which the external power acts on it. Self-oscillators are therefore distinct from forced and parametric resonators, in which the power that sustains the motion must be modulated externally. In linear systems, self-oscillation appears as an instability associated with a negative damping term, which causes small perturbations to grow exponentially in amplitude.
Negative resistanceIn electronics, negative resistance (NR) is a property of some electrical circuits and devices in which an increase in voltage across the device's terminals results in a decrease in electric current through it. This is in contrast to an ordinary resistor in which an increase of applied voltage causes a proportional increase in current due to Ohm's law, resulting in a positive resistance. While a positive resistance consumes power from current passing through it, a negative resistance produces power.
Genetically modified organismA genetically modified organism (GMO) is any organism whose genetic material has been altered using genetic engineering techniques. The exact definition of a genetically modified organism and what constitutes genetic engineering varies, with the most common being an organism altered in a way that "does not occur naturally by mating and/or natural recombination". A wide variety of organisms have been genetically modified (GM), from animals to plants and microorganisms.
Dummy variable (statistics)In regression analysis, a dummy variable (also known as indicator variable or just dummy) is one that takes the values 0 or 1 to indicate the absence or presence of some categorical effect that may be expected to shift the outcome. For example, if we were studying the relationship between biological sex and income, we could use a dummy variable to represent the sex of each individual in the study. The variable could take on a value of 1 for males and 0 for females (or vice versa).
Categorical variableIn statistics, a categorical variable (also called qualitative variable) is a variable that can take on one of a limited, and usually fixed, number of possible values, assigning each individual or other unit of observation to a particular group or on the basis of some qualitative property. In computer science and some branches of mathematics, categorical variables are referred to as enumerations or enumerated types. Commonly (though not in this article), each of the possible values of a categorical variable is referred to as a level.
Genetically modified animalGenetically modified animals are animals that have been genetically modified for a variety of purposes including producing drugs, enhancing yields, increasing resistance to disease, etc. The vast majority of genetically modified animals are at the research stage while the number close to entering the market remains small. Genetic engineering techniquesThe process of genetically engineering mammals is a slow, tedious, and expensive process.
Van der Pol oscillatorIn the study of dynamical systems, the van der Pol oscillator (named for Dutch physicist Balthasar van der Pol) is a non-conservative, oscillating system with non-linear damping. It evolves in time according to the second-order differential equation where x is the position coordinate—which is a function of the time t—and μ is a scalar parameter indicating the nonlinearity and the strength of the damping. The Van der Pol oscillator was originally proposed by the Dutch electrical engineer and physicist Balthasar van der Pol while he was working at Philips.
Genetically modified plantGenetically modified plants have been engineered for scientific research, to create new colours in plants, deliver vaccines, and to create enhanced crops. Plant genomes can be engineered by physical methods or by use of Agrobacterium for the delivery of sequences hosted in T-DNA binary vectors. Many plant cells are pluripotent, meaning that a single cell from a mature plant can be harvested and then under the right conditions form a new plant.
RC circuitA resistor–capacitor circuit (RC circuit), or RC filter or RC network, is an electric circuit composed of resistors and capacitors. It may be driven by a voltage or current source and these will produce different responses. A first order RC circuit is composed of one resistor and one capacitor and is the simplest type of RC circuit. RC circuits can be used to filter a signal by blocking certain frequencies and passing others.
