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Publication
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Work with us on data science and visualisation projects, and deploy your project as an app on top of Graph Search.
Syntheses of (-)-deoxoprosophylline from chiral L-N,N-di(benzyl)serine (TBDMS) aldehyde is reported. A highly diastereoselective nucleophilic addn. of Buechi's Grignard reagent to chiral serinal followed by an intramol. reductive amination of w-oxo amino diol are two key steps of the present synthesis. The target compd. was (2S,3R,6R)-6-dodecyl-3-hydroxy-2-piperidinemethanol, which is related to the Prosopis africana piperidine alkaloid family. [on SciFinder (R)]
Hatice Altug, Felix Ulrich Richter, Yasaman Jahani, Rui Lu, Bang Hyun Lee, Ming-Lun Tseng, Longfang Ye
Oleg Yazyev, Jan Hugo Dil, Quansheng Wu, Shengnan Zhang
Majed Chergui, Oliviero Cannelli, Giulia Fulvia Mancini, Malte Oppermann, Camila Bacellar Cases Da Silveira, Dominik Kinschel, Christian David, Jérôme Lacour