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Solid phase syntheses of the OF4949 derivs. I (R = H, CH2CONH2) and II (R1 = H, R2 = H, NH2; R1 = NH2, R2 = H) were performed via protection/deprotection of tyrosine side chains on a support, and SNAr macrocyclization reactions. [on SciFinder (R)]
Nako Nakatsuka, Xinyu Zhang, Haiying Hu