Publication
Synthesis of a model bicyclic C-O-D-O-E ring of vancomycin by a one-pot, double SNAr based macrocyclization
Related concepts (10)
Utility bicycle
A utility bicycle, city bicycle, urban bicycle, European city bike (ECB), Dutch bike, classic bike or simply city-bike, is a bicycle designed for frequent very short, very slow rides through very flat urban areas. It is a form of utility bicycle commonly seen around the world, built to facilitate everyday short-distance riding (no more than 5-6 km a day) in normal clothes in cold-to-mild weather conditions.
Folding bicycle
A folding bicycle is a bicycle designed to fold into a compact form, facilitating transport and storage. When folded, the bikes can be more easily carried into buildings, on public transportation (facilitating mixed-mode commuting and bicycle commuting), and more easily stored in compact living quarters or aboard a car, boat or plane. Folding mechanisms vary, with each offering a distinct combination of folding speed, folding ease, compactness, ride, weight, durability, complexity and price.
Bicycle
A bicycle, also called a pedal cycle, bike, push-bike or cycle, is a human-powered or motor-powered assisted, pedal-driven, single-track vehicle, having two wheels attached to a frame, one behind the other. A is called a cyclist, or bicyclist. Bicycles were introduced in the 19th century in Europe. By the early 21st century there were more than 1 billion. These numbers far exceed the number of cars, both in total and ranked by the number of individual models produced. They are the principal means of transportation in many regions.
Bicycle frame
A bicycle frame is the main component of a bicycle, onto which wheels and other components are fitted. The modern and most common frame design for an upright bicycle is based on the safety bicycle, and consists of two triangles: a main triangle and a paired rear triangle. This is known as the diamond frame. Frames are required to be strong, stiff and light, which they do by combining different materials and shapes. A frameset consists of the frame and fork of a bicycle and sometimes includes the headset and seat post.
Recumbent bicycle
A recumbent bicycle is a bicycle that places the rider in a laid-back reclining position. Most recumbent riders choose this type of design for ergonomic reasons: the rider's weight is distributed comfortably over a larger area, supported by back and buttocks. On a traditional upright bicycle, the body weight rests entirely on a small portion of the sitting bones, the feet, and the hands. Most recumbent models also have an aerodynamic advantage; the reclined, legs-forward position of the rider's body presents a smaller frontal profile.
Bicycle-sharing system
A bicycle-sharing system, bike share program, public bicycle scheme, or public bike share (PBS) scheme, is a shared transport service where bicycles are available for shared use by individuals at low cost. The programmes themselves include both docking and dockless systems, where docking systems allow users to rent a bike from a dock, i.e., a technology-enabled bicycle rack and return at another node or dock within the system – and dockless systems, which offer a node-free system relying on smart technology.
Peptidoglycan
Peptidoglycan or murein is a unique large macromolecule, a polysaccharide, consisting of sugars and amino acids that forms a mesh-like peptidoglycan layer outside the plasma membrane, the rigid cell wall (murein sacculus) characteristic of most bacteria (domain Bacteria). The sugar component consists of alternating residues of β-(1,4) linked N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM). Attached to the N-acetylmuramic acid is an oligopeptide chain made of three to five amino acids.
Penicillin
Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from Penicillium moulds, principally P. chrysogenum and P. rubens. Most penicillins in clinical use are synthesised by P. chrysogenum using deep tank fermentation and then purified. A number of natural penicillins have been discovered, but only two purified compounds are in clinical use: penicillin G (intramuscular or intravenous use) and penicillin V (given by mouth).
Rankine cycle
The Rankine cycle is an idealized thermodynamic cycle describing the process by which certain heat engines, such as steam turbines or reciprocating steam engines, allow mechanical work to be extracted from a fluid as it moves between a heat source and heat sink. The Rankine cycle is named after William John Macquorn Rankine, a Scottish polymath professor at Glasgow University. Heat energy is supplied to the system via a boiler where the working fluid (typically water) is converted to a high pressure gaseous state (steam) in order to turn a turbine.
Brayton cycle
The Brayton cycle is a thermodynamic cycle that describes the operation of certain heat engines that have air or some other gas as their working fluid. The original Brayton engines used a piston compressor and piston expander, but modern gas turbine engines and airbreathing jet engines also follow the Brayton cycle. Although the cycle is usually run as an open system (and indeed must be run as such if internal combustion is used), it is conventionally assumed for the purposes of thermodynamic analysis that the exhaust gases are reused in the intake, enabling analysis as a closed system.