History of Central AsiaThe history of Central Asia concerns the history of the various peoples that have inhabited Central Asia. The lifestyle of such people has been determined primarily by the area's climate and geography. The aridity of the region makes agriculture difficult and distance from the sea cut it off from much trade. Thus, few major cities developed in the region. Nomadic horse peoples of the steppe dominated the area for millennia. Relations between the steppe nomads and the settled people in and around Central Asia were marked by conflict.
TuberculosisTuberculosis (TB) is an infectious disease usually caused by Mycobacterium tuberculosis (MTB) bacteria. Tuberculosis generally affects the lungs, but it can also affect other parts of the body. Most infections show no symptoms, in which case it is known as latent tuberculosis. Around 10% of latent infections progress to active disease which, if left untreated, kill about half of those affected. Typical symptoms of active TB are chronic cough with blood-containing mucus, fever, night sweats, and weight loss.
Mycobacterium lepraeMycobacterium leprae (also known as the leprosy bacillus or Hansen's bacillus) is one of the two species of bacteria that cause Hansen’s disease (leprosy), a chronic but curable infectious disease that damages the peripheral nerves and targets the skin, eyes, nose, and muscles. It is an acid-fast, Gram-positive, rod shaped bacterium and an obligate intracellular parasite, which means, unlike its relative Mycobacterium tuberculosis, it cannot be grown in cell-free laboratory media.
Buddhism in Central AsiaBuddhism in Central Asia refers to the forms of Buddhism (mainly Mahayana) that existed in Central Asia, which were historically especially prevalent along the Silk Road. The history of Buddhism in Central Asia is closely related to the Silk Road transmission of Buddhism during the first millennium of the common era. A number of Early Buddhist schools were historically prevalent throughout Central Asia.
Single-nucleotide polymorphismIn genetics and bioinformatics, a single-nucleotide polymorphism (SNP snɪp; plural SNPs snɪps) is a germline substitution of a single nucleotide at a specific position in the genome that is present in a sufficiently large fraction of considered population (generally regarded as 1% or more). For example, a G nucleotide present at a specific location in a reference genome may be replaced by an A in a minority of individuals. The two possible nucleotide variations of this SNP – G or A – are called alleles.
Gene polymorphismA gene is said to be polymorphic if more than one allele occupies that gene's locus within a population. In addition to having more than one allele at a specific locus, each allele must also occur in the population at a rate of at least 1% to generally be considered polymorphic. Gene polymorphisms can occur in any region of the genome. The majority of polymorphisms are silent, meaning they do not alter the function or expression of a gene. Some polymorphisms are visible.
Genetic markerA genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species. It can be described as a variation (which may arise due to mutation or alteration in the genomic loci) that can be observed. A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change (single nucleotide polymorphism, SNP), or a long one, like minisatellites. For many years, gene mapping was limited to identifying organisms by traditional phenotypes markers.
MicrosatelliteA microsatellite is a tract of repetitive DNA in which certain DNA motifs (ranging in length from one to six or more base pairs) are repeated, typically 5–50 times. Microsatellites occur at thousands of locations within an organism's genome. They have a higher mutation rate than other areas of DNA leading to high genetic diversity. Microsatellites are often referred to as short tandem repeats (STRs) by forensic geneticists and in genetic genealogy, or as simple sequence repeats (SSRs) by plant geneticists.
KhwarazmKhwarazm (xwəˈræzəm; Old Persian: Hwârazmiya; خوارزم, Xwârazm or Xârazm) or Chorasmia (kəˈræzmiə) is a large oasis region on the Amu Darya river delta in western Central Asia, bordered on the north by the (former) Aral Sea, on the east by the Kyzylkum Desert, on the south by the Karakum Desert, and on the west by the Ustyurt Plateau. It was the center of the Iranian Khwarezmian civilization, and a series of kingdoms such as the Afrighid dynasty and the Anushtegin dynasty, whose capitals were (among others) Kath, Gurganj (now Konye-Urgench) and – from the 16th century on – Khiva.
Polymorphism (biology)In biology, polymorphism is the occurrence of two or more clearly different morphs or forms, also referred to as alternative phenotypes, in the population of a species. To be classified as such, morphs must occupy the same habitat at the same time and belong to a panmictic population (one with random mating). Put simply, polymorphism is when there are two or more possibilities of a trait on a gene. For example, there is more than one possible trait in terms of a jaguar's skin colouring; they can be light morph or dark morph.
