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MIMAS 3.0 is a Multiomics Information Management and Annotation System

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Early stirrings of landscape genomics: Awaiting next-next generation sequencing platforms before take-off

Stéphane Joost

Landscape genomics is an emerging research field that bridges genetics and genomics to geo-environmental resources analysis. It aims to study genome/environment interaction to discover the genetic basis of adaptation by processing of many simultaneous DNA- ...

Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture2010

Processing and analyzing ChIP-seq data: from short reads to regulatory interactions

Jacques Rougemont, Marion Leleu

Chromatin-immunoprecipitation and sequencing (ChIP-seq) is a rapidly maturing technology that draws on the power of high-throughput short-read sequencing to decipher chromatin states with unprecedented precision and breadth. Although some aspects of the ex ...

2010

Next-generation DNA sequencing techniques

Wilhelm Ansorge

Next-generation high-throughput DNA sequencing techniques are opening fascinating opportunities in the life sciences. Novel fields and applications in biology and medicine are becoming a reality, beyond the genomic sequencing which was original development ...

2009

Accurate whole human genome sequencing using reversible terminator chemistry

Gerardo Turcatti, Ho Ling Li, Lu Zhang, Anil Kumar, Jingwen Wang

DNA sequence information underpins genetic research, enabling discoveries of important biological or medical benefit. Sequencing projects have traditionally used long (400-800 base pair) reads, but the existence of reference sequences for the human and man ...

2008

Modeling sequencing errors by combining Hidden Markov models

Philipp Bucher

Among the largest resources for biological sequence data is the large amount of expressed sequence tags (ESTs) available in public and proprietary databases. ESTs provide information on transcripts but for technical reasons they often contain sequencing er ...

2003

Mycobacterial genomics

Stewart Cole

The small size of their genomes made bacterial ideal model organisms for the emerging field of genomics. Elucidating the genome sequences of mycobacteria was particularly attractive owing to the difficulties inherent in their manipulation. The slow growth ...

2002