Antibiotic sensitivity testingAntibiotic sensitivity testing or antibiotic susceptibility testing is the measurement of the susceptibility of bacteria to antibiotics. It is used because bacteria may have resistance to some antibiotics. Sensitivity testing results can allow a clinician to change the choice of antibiotics from empiric therapy, which is when an antibiotic is selected based on clinical suspicion about the site of an infection and common causative bacteria, to directed therapy, in which the choice of antibiotic is based on knowledge of the organism and its sensitivities.
Antimicrobial resistanceAntimicrobial resistance (AMR) occurs when microbes evolve mechanisms that protect them from the effects of antimicrobials (drugs used to treat infections). All classes of microbes can evolve resistance where the drugs are no longer effective. Fungi evolve antifungal resistance. Viruses evolve antiviral resistance. Protozoa evolve antiprotozoal resistance, and bacteria evolve antibiotic resistance. Together all of these come under the umbrella of antimicrobial resistance.
Lake GenevaLake Geneva (le Léman lə lemɑ̃, lac Léman lak lemɑ̃, rarely lac de Genève lak də ʒ(ə)nɛv; Lago Lemano; Genfersee ˈɡɛnfərˌzeː; Lai da Genevra) is a deep lake on the north side of the Alps, shared between Switzerland and France. It is one of the largest lakes in Western Europe and the largest on the course of the Rhône. Sixty per cent () of the lake belongs to Switzerland (the cantons of Vaud, Geneva and Valais) and forty per cent () to France (the department of Haute-Savoie).
AntibioticAn antibiotic is a type of antimicrobial substance active against bacteria. It is the most important type of antibacterial agent for fighting bacterial infections, and antibiotic medications are widely used in the treatment and prevention of such infections. They may either kill or inhibit the growth of bacteria. A limited number of antibiotics also possess antiprotozoal activity. Antibiotics are not effective against viruses such as the common cold or influenza; drugs which inhibit growth of viruses are termed antiviral drugs or antivirals rather than antibiotics.
Beta-lactam antibioticsβ-lactam antibiotics (beta-lactam antibiotics) are antibiotics that contain a beta-lactam ring in their chemical structure. This includes penicillin derivatives (penams), cephalosporins and cephamycins (cephems), monobactams, carbapenems and carbacephems. Most β-lactam antibiotics work by inhibiting cell wall biosynthesis in the bacterial organism and are the most widely used group of antibiotics. Until 2003, when measured by sales, more than half of all commercially available antibiotics in use were β-lactam compounds.
GenevaGeneva (dʒəˈniːvə ; Genève ʒənɛv) is the second-most populous city in Switzerland (after Zürich) and the most populous city of Romandy, the French-speaking part of Switzerland. Situated in the south west of the country, where the Rhône exits Lake Geneva, it is the capital of the Republic and Canton of Geneva, and a center for international diplomacy. The city of Geneva (ville de Genève) had a population of 203,951 in 2020 (Jan. estimate) within its small municipal territory of , but the Canton of Geneva (the city and its closest Swiss suburbs and exurbs) had a population of 504,128 (Jan.
Clostridioides difficile infectionClostridioides difficile infection (CDI or C-diff), also known as Clostridium difficile infection, is a symptomatic infection due to the spore-forming bacterium Clostridioides difficile. Symptoms include watery diarrhea, fever, nausea, and abdominal pain. It makes up about 20% of cases of antibiotic-associated diarrhea. Antibiotics can contribute to detrimental changes in gut microbiota; specifically, they decrease short-chain fatty acid absorption which results in osmotic, or watery, diarrhea.
LausanneLausanne (loʊˈzæn , USalsoloʊˈzɑːn , lɔzan; Losena lɔˈzəna) is the capital and largest city of the Swiss French-speaking canton of Vaud. It is a hilly city situated on the shores of Lake Geneva, about halfway between the Jura Mountains and the Alps, and facing the French town of Évian-les-Bains across the lake. Lausanne is located northeast of Geneva, the nearest major city. The municipality of Lausanne has a population of about 140,000, making it the fourth largest city in Switzerland after Basel, Geneva, and Zurich, with the entire agglomeration area having about 420,000 inhabitants (as of January 2019).
Antibiotic use in livestockAntibiotic use in livestock is the use of antibiotics for any purpose in the husbandry of livestock, which includes treatment when ill (therapeutic), treatment of a group of animals when at least one is diagnosed with clinical infection (metaphylaxis), and preventative treatment (prophylaxis). Antibiotics are an important tool to treat animal as well as human disease, safeguard animal health and welfare, and support food safety. However, used irresponsibly, this may lead to antibiotic resistance which may impact human, animal and environmental health.
Canton of GenevaThe Canton of Geneva, officially the Republic and Canton of Geneva, is one of the 26 cantons forming the Swiss Confederation. It is composed of forty-five municipalities, and the seat of the government and parliament is in the City of Geneva. Geneva is the French-speaking westernmost canton of Switzerland. It lies at the western end of Lake Geneva and on both sides of the Rhone, its main river. Within the country, the canton shares borders with Vaud to the east, the only adjacent canton.
