Publications related to Development and Understanding of Novel Compounds Designed as Potential MRI Contrast Agents

Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI

To enhance the success rate of antiangiogenic therapies in the clinic, it is crucial to identify parameters for tumour angiogenesis that can predict response to these therapies. In brain tumours, one such parameter is vascular leakage, which is a response ...

Nature Publishing Group2008

Theoretical investigations of magnetic properties of MRI contrast agents and carbon nanostructures

Oleg Yazyev

The phenomenon of magnetism is one of the key components of today's technological progress. Magnetic interactions and magnetic materials are essential for the scientific disciplines of physics, chemistry and biology, making this subject truly multidiscipli ...

EPFL2007

Gadolinium(III) ion in liquid water: structure, dynamics and magnetic interactions from first principles

Lothar Helm, Oleg Yazyev

We applied first principles molecular dynamics (MD) technique to study structure, dynamics, and magnetic interactions of the

Gd^{3+}

aqua ion dissolved in liquid water, a prototypical system for Gd-based complexes used as contrast agents for magnetic res ...

2007

Magnetic resonance imaging and T2 relaxometry of human median nerve at 7 Tesla

Giulio Gambarota

Measurements of T2 relaxation times in tissues have provided a unique, noninvasive method to investigate the microenvironment of water molecules in vivo. As more clinical imaging is performed at higher field strengths, tissue relaxation times need to be re ...

Wiley-Blackwell2007

Design of Gd(III)-Based Magnetic Resonance Imaging Contrast Agents: Static and Transient Zero-Field Splitting Contributions to the Electronic Relaxation and Their Impact on Relaxivity

André Merbach, Lothar Helm, Alain Borel, Loïck Moriggi

A multiple-frequency (9.4-325 GHz) and variable-temperature (276-320 K) electron paramagnetic resonance (EPR) study on low molecular weight gadolinium(III) complexes for potential use as magnetic resonance imaging (MRI) contrast agents has been performed. ...

2007

Multiple-frequency EPR spectra of two aqueous Gd3+ polyaminopolypyridinecarboxylate complexes: a study of high field effects

Lothar Helm, Marinella Mazzanti, Alain Borel, Sabrina Laus

In the search for highly efficient magnetic resonance imaging contrast agents, polyaminopolypyridinecarboxylate complexes of Gd3+ have shown unusual properties with both very rapid and very slow electron spin relaxation in solution observed by electron par ...

2007

Multifrequency EPR studies of zero field splitting of Gd(III) based MRI contrast agents in solids and liquids

Magnetic Resonance Imaging (MRI) offers an amazing number of ways to probe the human body. It is a wonderful symbiosis of engineering, science and medicine. The power of MRI is its ability to probe a variety of physical mechanisms that can then not only re ...

EPFL2006

Phosphinic derivative of DTPA conjugated to a G5 PAMAM dendrimer: an 17O and 1H relaxation study of its Gd(III) complex

André Merbach, Lothar Helm, Eva Jakab Toth, Petra Lebduskova

A DTPA-based chelate containing one phosphinate group was conjugated to a generation 5 polyamidoamine (PAMAM) dendrimer via a benzylthiourea linkage. The Gd(III) complex of this novel conjugate has potential as a contrast agent for magnetic resonance imagi ...

2006

New strategies for highly efficient MRI contrast agents

Joao Bruno Livramento Fig.

The 2003 Nobel Prize in Medicine or Physiology has been awarded for discoveries concerning Magnetic Resonance Imaging (MRI), a technique that revolutionalized medical diagnostics over the last two decades. Such spectacular development would not have been p ...

EPFL2006

Novel chelators for MRI applications

In the last two decades, Magnetic Resonance Imaging (MRI) has evolved into one of the most powerful techniques in diagnostic clinical medicine and biomedical research. MRI is primarily used to produce anatomical images, but may also give information on the ...

EPFL2006

Development and Understanding of Novel Compounds Designed as Potential MRI Contrast Agents

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Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI

Theoretical investigations of magnetic properties of MRI contrast agents and carbon nanostructures

Gadolinium(III) ion in liquid water: structure, dynamics and magnetic interactions from first principles

Magnetic resonance imaging and T2 relaxometry of human median nerve at 7 Tesla

Design of Gd(III)-Based Magnetic Resonance Imaging Contrast Agents: Static and Transient Zero-Field Splitting Contributions to the Electronic Relaxation and Their Impact on Relaxivity

Multiple-frequency EPR spectra of two aqueous Gd3+ polyaminopolypyridinecarboxylate complexes: a study of high field effects

Multifrequency EPR studies of zero field splitting of Gd(III) based MRI contrast agents in solids and liquids

Phosphinic derivative of DTPA conjugated to a G5 PAMAM dendrimer: an 17O and 1H relaxation study of its Gd(III) complex

New strategies for highly efficient MRI contrast agents

Novel chelators for MRI applications

Theoretical investigations of magnetic properties of MRI contrast agents and carbon nanostructures

New strategies for highly efficient MRI contrast agents

Characterisation of tumour vasculature in mouse brain by USPIO contrast-enhanced MRI

Magnetic resonance imaging and T2 relaxometry of human median nerve at 7 Tesla

Design of Gd(III)-Based Magnetic Resonance Imaging Contrast Agents: Static and Transient Zero-Field Splitting Contributions to the Electronic Relaxation and Their Impact on Relaxivity

Multifrequency EPR studies of zero field splitting of Gd(III) based MRI contrast agents in solids and liquids

Gadolinium(III) ion in liquid water: structure, dynamics and magnetic interactions from first principles

Multiple-frequency EPR spectra of two aqueous Gd3+ polyaminopolypyridinecarboxylate complexes: a study of high field effects

Novel chelators for MRI applications

Phosphinic derivative of DTPA conjugated to a G5 PAMAM dendrimer: an 17O and 1H relaxation study of its Gd(III) complex