Adaptive design (medicine)In an adaptive design of a clinical trial, the parameters and conduct of the trial for a candidate drug or vaccine may be changed based on an interim analysis. Adaptive design typically involves advanced statistics to interpret a clinical trial endpoint. This is in contrast to traditional single-arm (i.e. non-randomized) clinical trials or randomized clinical trials (RCTs) that are static in their protocol and do not modify any parameters until the trial is completed.
Observational errorObservational error (or measurement error) is the difference between a measured value of a quantity and its true value. In statistics, an error is not necessarily a "mistake". Variability is an inherent part of the results of measurements and of the measurement process. Measurement errors can be divided into two components: random and systematic. Random errors are errors in measurement that lead to measurable values being inconsistent when repeated measurements of a constant attribute or quantity are taken.
Asynchronous serial communicationAsynchronous serial communication is a form of serial communication in which the communicating endpoints' interfaces are not continuously synchronized by a common clock signal. Instead of a common synchronization signal, the data stream contains synchronization information in form of start and stop signals, before and after each unit of transmission, respectively. The start signal prepares the receiver for arrival of data and the stop signal resets its state to enable triggering of a new sequence.
BrainGateBrainGate is a brain implant system built and previously owned by Cyberkinetics, currently under development and in clinical trials, designed to help those who have lost control of their limbs, or other bodily functions, such as patients with amyotrophic lateral sclerosis (ALS) or spinal cord injury. The Braingate technology and related Cyberkinetic’s assets are now owned by privately held Braingate, Co. The sensor, which is implanted into the brain, monitors brain activity in the patient and converts the intention of the user into computer commands.
Phase transitionIn chemistry, thermodynamics, and other related fields, a phase transition (or phase change) is the physical process of transition between one state of a medium and another. Commonly the term is used to refer to changes among the basic states of matter: solid, liquid, and gas, and in rare cases, plasma. A phase of a thermodynamic system and the states of matter have uniform physical properties. During a phase transition of a given medium, certain properties of the medium change as a result of the change of external conditions, such as temperature or pressure.
Mode (user interface)In user interface design, a mode is a distinct setting within a computer program or any physical machine interface, in which the same user input will produce perceived results different from those that it would in other settings. Modal interface components include the Caps lock and Insert keys on the standard computer keyboard, both of which typically put the user's typing into a different mode after being pressed, then return it to the regular mode after being re-pressed. An interface that uses no modes is known as a modeless interface.
Comparison of synchronous and asynchronous signallingSynchronous and asynchronous transmissions are two different methods of transmission synchronization. Synchronous transmissions are synchronized by an external clock, while asynchronous transmissions are synchronized by special signals along the transmission medium. Whenever an electronic device transmits digital (and sometimes analogue) data to another, there must be a certain rhythm established between the two devices, i.e.
MetrologyMetrology is the scientific study of measurement. It establishes a common understanding of units, crucial in linking human activities. Modern metrology has its roots in the French Revolution's political motivation to standardise units in France when a length standard taken from a natural source was proposed. This led to the creation of the decimal-based metric system in 1795, establishing a set of standards for other types of measurements.
Asynchronous I/OIn computer science, asynchronous I/O (also non-sequential I/O) is a form of input/output processing that permits other processing to continue before the transmission has finished. A name used for asynchronous I/O in the Windows API is overlapped I/O. Input and output (I/O) operations on a computer can be extremely slow compared to the processing of data. An I/O device can incorporate mechanical devices that must physically move, such as a hard drive seeking a track to read or write; this is often orders of magnitude slower than the switching of electric current.
Open-source hardwareOpen-source hardware (OSH) consists of physical artifacts of technology designed and offered by the open-design movement. Both free and open-source software (FOSS) and open-source hardware are created by this open-source culture movement and apply a like concept to a variety of components. It is sometimes, thus, referred to as FOSH (free and open-source hardware). The term usually means that information about the hardware is easily discerned so that others can make it – coupling it closely to the maker movement.
